Program Executive, Drug Development and Commercial

Praxis Precision Medicines; United States; Remote; USD 285,000 - 325,000; Full time

Benefits offered by this job

Medical/dental/vision

401(k) match

Stock incentives

ESPP

Job summary

Praxis Precision Medicines is seeking a seasoned Program Lead to drive a high-impact development program in the United States. You will shepherd strategy and execution across research, development, operations, and commercialization, aligning cross-functional teams to deliver results with ownership and accountability.

The role emphasizes rigorous decision-making, bold vision, and collaboration in a fast-paced, flat organization.

Qualifications

• Demonstrated drug development experience with cross-functional leadership.
• Ability to translate strategy into executable plans across development stages.
• Strong communication with internal and external stakeholders.
• Comfort operating in high-ambiguity, fast-moving environments.

Responsibilities

• Communicate a bold, shared vision for the program externally and internally.
• Lead and maintain the Program Team with clear accountability for decisions.
• Devise and execute the program strategy and integrated development plan.
• Define OKRs and oversee budgets, resourcing, and investments.
• Ensure efficient, high-quality execution and cross-functional alignment.
• Serve as the primary integration point with corporate processes.

Skills

Cross-functional leadership

Drug development

Strategic thinking

Stakeholder communication

Job description

Location: United States

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

Praxis is looking for a talented and experienced leader for a key program expected to advance best in class or first-in-class products for areas of high unmet medical need. The ideal candidate is a strong, multi-faceted leader who thrives in environments with high ambiguity, limited hierarchy, and real ownership of outcomes as the program continues its rapid trajectory of transformational patient impact.

This results-oriented individual will be characterized by a strong strategic mind, a collaborative nature and intellectual curiosity, and will credibly and enthusiastically work across the spectrum of research, development, technical operations, and commercialization. They will lead a cross-functional program team and be responsible and accountable for Praxis’ program strategy, driving decision‑making, and ensuring efficient and high‑quality execution.

Praxis is committed to a high‑energy, fast‑pace and flat organization where individuals work as peers with singular objective to bring drugs to patients. This role is not about coordinating consensus; it is about building alignment, deeply understanding all aspects of the development activities for the product and driving the program forward. The Program Lead must embrace and exemplify this way of working.

Primary Responsibilities

• Internally and externally communicate a shared and bold vision for the program.
• Lead, manage, and maintain the Program Team, partnering with functional leads to ensure team effectiveness and operational excellence while retaining clear accountability for program‑level decisions.
• Lead the creation and execution of the program strategy and integrated development plan(s).
• In collaboration with the Program Team, define and deliver against program OKRs.
• Provide strategic oversight for program budgets and resourcing, actively shaping—not just tracking—investment decisions.
• Architect scenarios to inform decision making and program planning; ensure that the right skills and capabilities exist on the team to effectively execute on the program plan.
• Be a role model for Praxons: inspire ambitious goals, give and receive direct feedback, and build trust through transparency and follow‑through.
• "Roll up sleeves and get hands dirty" for the benefit of the team and the program; wear multiple hats, step into gaps, and hold yourself to the same standards as the team.
• Serve as the primary integration point with corporate processes without creating unnecessary bureaucracy.

Qualifications and Key Success Factors

• Demonstrated drug development experience with a strong track record of cross‑functional leadership; experience across the full development lifecycle strongly preferred
• Strong holistic understanding of the drug development process across functions
• Ability to translate strategy into execution, driving decisions that create value under real‑world constraints
• Clear, compelling communicator across internal and external stakeholders

What Sets Successful Praxons Apart

• Comfort operating with limited hierarchy and high personal accountability
• Learning agility and intellectual curiosity; ability to rapidly develop deep understanding of new therapeutic areas
• Willingness to challenge assumptions, surface risks early, and engage in healthy debate in service of the best outcome
• Demonstrated ability to balance urgency with rigor in fast‑moving environments

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Annualized Base Salary

$285,000—$325,000 USD

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company‑paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.Thinking about the future? We match dollar‑for‑dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long‑term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company‑wide shutdowns. Not to mention, you’ll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical‑stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion

Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.