Production Sequencing Lead

Basecamp Research; Boston (MA); On-site; GBP 90,000 - 130,000; Full time

Benefits offered by this job

Impactful mission

Collaborative culture

Career growth

Competitive benefits

Job summary

Basecamp Research is building frontier AI for therapeutic design with a focus on scalable production pipelines. The Senior Production role will own the sample-to-sequence process end-to-end, driving throughput and translating R&D into robust, scalable workflows.

You will lead a production team, implement Lean/Six Sigma improvements, and coordinate with data and bioinformatics partners to ensure high-quality results as the Atlas scales in Phase 2. London and Boston offices support collaboration.

Qualifications

• 5+ years in a production-based environment for high-throughput sequencing.
• Expertise with short-read (Illumina) and long-read (PacBio/Nanopore) platforms and library prep workflows.
• Proven Lean / Six Sigma application in a laboratory setting to reduce waste and improve throughput.
• Experience with laboratory automation: developing and maintaining automated liquid handling and sample processing workflows.
• Strong leadership: managing production schedules, resources, and multi-person workflows under throughput pressure.

Responsibilities

• Own the TGA production pipeline end-to-end for sample processing from DNA extraction to sequencing dispatch.
• Lead technical transfer from R&D into production, ensuring methods scale reliably at volume.
• Drive continuous improvement using Lean/Six Sigma to shorten turnaround times and reduce variability.
• Monitor data input and pipeline health, coordinate with data suppliers and bioinformatics teams to ensure high-quality data flow.
• Lead and develop the production team, mentoring staff and building a culture of precision and pace as the Atlas scales.
• Horizon-scan and deploy new sequencing technologies and workflow innovations aligned with production targets.

Skills

People leadership

Lean Six Sigma

Laboratory automation

Production scheduling

LIMS (Benchling)

Cross-functional collaboration

Tools

Benchling

Illumina

PacBio

Oxford Nanopore

Job description

Basecamp Research is building frontier AI for therapeutic design. We believe the future of medicine lies in reprogramming the body to repair itself, and we design the models and the medicines to teach it how.

Our EDEN models are trained on BaseData, the world's largest proprietary genomic dataset, with over 10B genes collected through partnerships in more than 30 countries across all seven continents. This gives our AI models access to genetic diversity that doesn't exist in public databases, and enables EDEN to design cell and gene therapies, enzymes, and peptides directly from information about a disease. Our pipeline of EDEN-designed therapeutics, beginning with in vivo cell therapy, is advancing towards clinical development.

In September 2026 we closed an oversubscribed $140M Series C led by S32, with participation from NVIDIA, Anthropic's Anthology Fund, Catalio, European Tech Collective, Firebrand River Capital, King Philanthropies, NATO Innovation Fund, NVentures (NVIDIA's venture arm), Redalpine, Rockefeller Foundation, Singular, Sovereign AI and True Ventures. We have offices and labs in London and Boston, we partner with biopharma companies and academic institutions worldwide, and our work has been recognised by Fast Company's Top 10 Most Innovative Companies in Biotech, the FT-backed Sifted AI100 list of Europe's leading AI startups as well as Barclays Eagle Labs Ones to watch, AI100.

At Basecamp Research, we pride ourselves on being a lean collaborative and global team with extremely specialist and unique skills. Our biologists, engineers, ML scientists and field explorers are united by a sense of adventure and the belief that AI, biology and data, will result in new medicines for patients who have few options today.

The Role

This role is the operational spine of the Trillion Gene Atlas. You will own the sample-to-sequence pipeline end-to-end, driving throughput, translating R&D into production, and leading the team that keeps the Atlas growing.

• Own the TGA production pipeline.Provide agile, end-to-end management of the sample processing pipeline across Phase 1 and Phase 2 - from DNA extraction through library preparation and sequencing dispatch. You set the pace and hold the targets.
• Lead technical transfer from R&D into production.Work closely with our R&D team to translate validated protocols into robust, scalable production workflows. You are the bridge between experimental and operational - ensuring new methods land cleanly and run reliably at volume.
• Drive continuous improvement.Apply Lean / Six Sigma principles to continuously improve turnaround times, reduce variability, and increase throughput. Identify bottlenecks, implement fixes, and build improvements back into the standard workflow.
• Monitor data input and pipeline health. Work with data suppliers and internal bioinformatics teams to ensure smooth, high-quality data return from sequencing partners. Track key metrics, flag issues early, and close the loop between production and downstream analysis.
• Lead and develop the production team.You will be the operational lead for the TGA lab team - managing day-to-day workflow, mentoring junior staff, and building a culture of precision, accountability, and pace as we scale through Phase 2.
• Horizon scan and deploy new technologies. Stay ahead of emergent sequencing technologies, automation platforms, and workflow innovations. Evaluate fit for TGA production targets and move and sync quickly to pilot and implement where there is clear operational value.

Required Skills and Experience

• 5+ years working in a production-based environment for high-throughput sequencing, with a confident track record running a small team to deliver high-impact work on time.
• Deep familiarity with short-read (Illumina / Ultima) and long-read (PacBio / Nanopore) platforms and library preparation workflows end-to-end.
• Demonstrable track record applying Lean / Six Sigma in a laboratory production setting - waste reduction, throughput improvement, SOP development.
• Experience with laboratory automation - developing, validating, and maintaining automated liquid handling and sample processing workflows.
• Strong team leadership capability - managing production schedules, resource allocation, and multi-person workflows under throughput pressure.
• Experience with LIMS platforms (Benchling or equivalent) for sample tracking and workflow management.
• Background in technical transfer and SOP writing for handoff between R&D and production teams.
• Comfort working across interdisciplinary teams, bioinformatics, data science, collaborations, to align production outputs with downstream analytical needs.

Advantageous Skills and Experience

• Hands-on DNA extraction experience across diverse sample types including soils, environmental, and biological matrices.
• Familiarity with multiplexed library preparation strategies for low-biomass and environmentally complex samples.
• Experience with metagenomic or environmental sequencing projects at scale.

What we offer in return

• Impactful Mission: This is a rare opportunity to do work that genuinely matters. You'll join a talented, fast-moving team, access unique biological datasets at scale, and see your contributions shape real breakthroughs in AI and curative therapeutics.
• Collaborative Culture: You'll be surrounded by world-class scientists, engineers, and researchers who care deeply about their work and about each other. With offices in Boston and London, we've built a flexible, cross-functional environment where personal development and real ownership aren't just talking points.
• High Growth: We truly believe in investing in our people and their development, we have twice yearly promotion opportunities. People who are really successful here own it and go directly to solve problems at pace and we ensure reward increases with impact.
• Comprehensive Benefits: We've built a benefits package people value. That means competitive salary, equity, pension plan, and healthcare so strong that most employees' family members opt into our plan over their own.

We are committed to equal opportunity employment regardless of ethnic or national origin, race, religion, sex, age, citizenship, sexual orientation, marital status, disability, gender identity or any other basis. If you have a disability or additional need that needs accommodating do let us know.