Product Manager - Upstream

Tech Ladies®; Madison (WI); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health, dental and vision coverage

401(k) with company match

Paid time off and holidays

Onsite wellness facilities

Job summary

OrganOx has an exciting career opportunity for a Product Manager, Upstream at our global headquarters in Oxford, UK. In this role you will oversee full lifecycle management for our portfolio with focus on early-stage innovation and foundational requirements for next-generation, connected medical devices.

You will translate clinical insights into PRDs, work with R&D, Regulatory, and Quality teams, and drive strategic initiatives to support commercial launch readiness.

Qualifications

• 7+ years of experience in medical device product management, upstream marketing, or product strategy.
• Demonstrated understanding of U.S. and global transplantation ecosystems from OPOs, transplant centers, or medical devices serving this sector.
• Proven history leading cross-functional teams to drive complex hardware/software/consumable systems through early development phases.

Responsibilities

• Own and define the 1.5-to-5-year global product roadmap for your clinical portfolio with alignment to growth targets.
• Lead strategic portfolio prioritization balancing disruptive innovation with incremental extensions.
• Monitor healthcare regulations, reimbursement shifts, and global trends to pivot strategy.
• Design and execute VOC strategies with advisory boards and research.
• Partner with KOLs and scientific communities to identify high-value clinical needs.
• Develop rigorous business cases with financial models and ROI metrics.

Skills

Clinical literacy

Design controls

Data analysis

Influence

Emotional intelligence

Travel

Education

Bachelor's degree in Biomedical Engineering or Mechanical Engineering or Life Sciences

MBA or advanced degree (MD/PhD/MS) preferred

Job description

All Jobs

OrganOx

Posted on

Oct 26, 2026

Product Manager - Upstream

Madison

Mid-Senior ICs

Marketing

OrganOx

www.organox.com

101-250

Medical Equipment Manufacturing

Transforming transplantation with the OrganOx metra®. A transportable, automated ex vivo liver perfusion device.

The core technology employed by the OrganOx metra® has been in development for over 15 years. During this time both of the founders (Professor Peter Friend and Professor Constantin Coussios) have driven the development of organ preservation and maintenance, formerly at the University of Cambridge and latterly at the University of Oxford.

OrganOx Limited was founded in April 2008 as a spin-out from the University of Oxford.

Conventional cold preservation involves storage of the liver at 4˚C, using a non-physiological perfusion solution that aims to minimise liver decay. By contrast, warm preservation seeks to re-create an environment that mimics the human body by continuously perfusing at physiological pressures and flows with oxygen-carrying red cells at 37˚C and providing nutrition. The liver is therefore functional during the preservation period, producing bile, metabolizing glucose and maintaining a physiological pH. This enables objective assessment of organ performance prior to transplant, extended preservation times, and the potential use of organs that are presently being discarded.

Job Description

ABOUT ORGANOX:

OrganOx is a commercial stage organ technology company dedicated to developing technologies to improve outcomes for patients with acute or chronic organ failure. The company was established as a spin out of the University of Oxford in 2008 and is now part of the Terumo Group. OrganOx is a pioneer in normothermic machine perfusion (NMP). It's flagship platform, the metra®, is available for use in the U.S., Europe, Canada, and Australia. It has been utilized in over 7,000 liver transplants to date to keep donor livers in a metabolically active state outside the body enabling longer preservation times and functional assessment of the organ prior to transplant, leading to an increased number of organs available for transplant. Founded in 1921, Terumo Corporation (TSE:4543) strives to fulfill its mission of "Contributing to Society through Healthcare" by providing a comprehensive range of solutions in the fields of therapeutic procedures, hospital operations, and life sciences in more than 160 countries and regions.

Position Summary

OrganOx has an exciting career opportunity for a Product Manager, Upstream at our global headquarters in Oxford, UK. In this role you will oversee full lifecycle management for our existing product portfolio with primary focus on early-stage innovation, strategic planning, and foundational requirements for our next-generation, connected medical device portfolio. You will act as the ultimate voice of the customer, bridging the gap between clinical needs and technical development. This role focuses on the "front end" of innovation—identifying high-value clinical opportunities, building business cases, and defining product requirements before handing off to downstream teams for commercial launch. You will report to the Global Director of Marketing.

Responsibilities

Under direction from the Director, Marketing the Product Manager, Upstream will be responsible for:

• Own and define the 1.5-to-5-year global product roadmap for your assigned clinical portfolio, ensuring alignment with corporate growth targets
• Lead strategic portfolio prioritization exercises, balancing disruptive innovation with incremental product line extensions
• Monitor changing healthcare regulations, policies governing organ donation and use, global macroeconomic healthcare trends, clinical literature, reimbursement shifts, and competitive intelligence to pivot strategy proactively

• Design and execute comprehensive global Voice of Customer (VOC) strategies, including advisory boards, primary and secondary research, and procedural observations
• Partner with Key Opinion Leaders (KOLs), medical advisory boards, and scientific communities to identify high-value unaddressed clinical needs
• Analyze international healthcare economics to integrate global pricing, reimbursement, and market-access requirements early in the product concept phase

• Author rigorous, executive-level business cases complete with complex financial models, target pricing, net present value (NPV) analytics, and risk assessments
• Drive funding approval through corporate Stage-Gate governance reviews by defending market assumptions and return on investment (ROI) metrics
• Partner with head of business development to provide commercial due diligence for external partnership, licensing, or acquisition (BD&L) opportunities

• Translate ambiguous clinical insights into precise, high-level Product Requirements Documents (PRDs) and system-level design inputs
• Represent the "commercial voice" in cross-functional core teams consisting of senior leaders from R&D, Clinical Affairs, Regulatory Affairs, Quality Engineering, and Operations
• Collaborate with regulatory teams to architect global submission strategies, identifying predicate devices and user-needs mapping for FDA (510k/PMA) and EU MDR compliance
• Ensure a seamless transition and hand-off to Downstream Product Management partners as the product approaches commercial launch readiness

Requirements

Required Qualifications and Experience

Education

• Bachelor's degree in Biomedical Engineering, Mechanical Engineering, Life Sciences, or a technical equivalent
• An MBA or advanced scientific degree (MD, PhD, MS) is preferred

Experience

• 7+ years of experience in medical device product management, upstream marketing, or product strategy
• Demonstrated understanding of the U.S. and global transplantation ecosystems derived from working with OPOs, transplant centers, or medical device companies that serve this sector
• Proven history of leading cross-functional teams to successfully drive complex class II or class III hardware/software/consumable systems through early development phases

Technical & Behavioral Skills

• Clinical Literacy: Comfort speaking with specialized clinicians regarding anatomy, biology, pathophysiology and the role that medical devices serve to improve health
• Design Control Competence: Strong working knowledge of early-stage medical device design standards and controls under ISO and FDA regulations
• Data Analysis/Synthesis: Strong financial acumen, data modeling capability, and experience turning raw objective and subjective data sets into summarized strategic insights and decision making
• Influence & Adaptability: Elite cross-functional communication skills to align often conflicting internal and external stakeholder interests
• High Emotional Intelligence: Self-awareness, self-regulation, and awareness of others' emotions to manage complex interactions across a broad range of stakeholders while still driving timelines and results
• Travel: Willingness to travel up to 30% globally for clinical site observations, conferences, and stakeholder interviews

A job description does not imply that the duties stated are the only ones to be performed by the job holder. Job holder will be required to follow any other job-related instruction as reasonably requested by their line manager or their designate.

Benefits

We offer competitive compensation and comprehensive benefits available from day one, including health, dental, vision, disability coverage, and flexible spending accounts. Additionally, we offer a 401(k)-retirement plan with company matching after 90 days, paid time off, holidays, and additional leave benefits, as well as employee discounts and access to our onsite wellness facility. OrganOx supports work-life balance and provides opportunities for ongoing professional development.

About The Job

Apply before November 21, 2026

Posted on

October 23, 2026

Experience level

Mid-Senior ICs

Salary

Job type

Location

Madison