Principal Scientist - Translational/Muscle Biologist

UCB Inc.; Cambridge (MA); On-site; USD 137,000 - 181,000; Full time

Job summary

An established industry player is seeking a Principal Scientist to join their US translational biology group in Cambridge, MA. This pivotal role involves leading innovative drug discovery efforts with a focus on muscle biology. The ideal candidate will design and validate advanced cellular models, conduct functional assays, and manage cross-functional projects. With a commitment to collaboration and scientific excellence, this position offers a unique opportunity to contribute to groundbreaking research that can significantly impact patient outcomes. If you are passionate about advancing science and making a difference, this role is for you.

Qualifications

• 12+ years in drug discovery or related field with a PhD.
• Experience in leading projects and mentoring scientists.

Responsibilities

• Lead projects in muscle biology and translational research.
• Supervise and mentor junior scientists in a collaborative environment.

Skills

Muscle Biology

Translational Assays

Assay Development

Project Management

Data Management

Education

PhD in Drug Discovery or Biology

MS Degree in Drug Discovery or Biology

Tools

Cell Culture Techniques

Biochemical Assays

Job description

JOB DESCRIPTION

Make your mark for patients

We are seeking a Principal Scientist to join the US translational biology group based in Cambridge, MA and contribute to translational biology drug discovery efforts with an emphasis on muscle biology. The candidate will be responsible for leading projects, exploring new biology, designing, characterizing and deploying stem cell/3D models and other cellular/biochemical assays to be utilized in early drug discovery for multiple therapeutic programs and target discovery efforts. Collaborate in a matrixed team of scientists responsible for identification and knowledge building across pathobiological pathways and patient populations including those in neuromuscular disease related to nucleotide repeat expansions, genetic mutations, mitochondrial dysfunction or inflammation.

Base Salary: $137,600 to $180,600

Responsibilities:

• Team leadership: Supervise and mentor junior scientists, fostering a collaborative and innovative research environment.
• Project management: Oversee multiple projects, ensuring timely delivery of milestones and effective resource allocation.
• Innovation: Identify and implement new technologies and methodologies to advance muscle cell biology and translational research.
• Model Development: Design, characterize and validate primary cell or stem cell/3D models for therapeutic programs.
• Assay Execution: Conduct cell-based functional assays to characterize therapeutic hits or validate new targets that could require gene editing.
• Translational Assays: Perform complex assays (2D to 3D models) to enhance understanding of neuromuscular disease biology.
• Team Collaboration: Collaborate with cross-functional teams to integrate translational biology insights into therapeutic programs or new target proposals.
• Data Management: Document, analyze, and present data to internal teams.

Requirements

• PhD with 12+ years or MS Degree with 18+ years in drug discovery, biology, cellular biology, bioengineering or related field.

Competencies

• Deep knowledge in muscle biology, and translational assays.
• Strong assay development and drug discovery knowledge
• Strong track record of publishing in high-impact journals and presenting at scientific conferences
• Deep experience with mammalian cell culture, molecular and biochemical assays.
• Strong attention to detail, and enthusiasm for learning.
• Proven ability to lead projects, supervise and mentor scientists is a plus

If you are interested to learn more about R&D within UCB, please find more information here R&D at UCB.

RANDATUCB

Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!

About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equitable opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

UCB is an equal opportunity employer. All qualified applicants will receive equal consideration for employment without regard to race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on [e-mail] for application to US based roles. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.