Principal Scientist, Real World Evidence

Crinetics Pharmaceuticals, Inc.; Headquarters (ID); Remote; USD 178,000 - 222,000; Full time

Job summary

Join a dynamic team at a leading pharmaceutical company focused on developing innovative therapies for endocrine diseases. As a Principal Scientist in Real World Evidence, you will play a critical role in generating evidence to support product launches and market access strategies. This position offers the opportunity to work closely with cross-functional teams and external partners, driving impactful research that shapes the future of patient care. If you're passionate about making a difference and thrive in a collaborative environment, this role is perfect for you.

Benefits

Health Insurance

401k Match

Discretionary Annual Bonus

20 Days PTO

10 Paid Holidays

Winter Company Shutdown

Stock Options

Qualifications

• 10+ years in pharmaceutical/consulting HEOR experience.
• Advanced degree required in health economics or related field.

Responsibilities

• Design and manage RWE studies for product lifecycle management.
• Collaborate with cross-functional teams for evidence generation.

Skills

Health Economics

Health Outcomes Research

Statistical Analysis

Real-World Data Analysis

Communication Skills

Leadership

Education

Advanced Degree (MSc, MPH, PhD, PharmD, RN, MD)

Tools

Electronic Health Records

Healthcare Databases

Job description

Principal Scientist, Real World Evidence page is loaded

Principal Scientist, Real World Evidence

Apply remote type Remote locations Remote time type Full time posted on Posted 11 Days Ago job requisition id JR000341

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Principal Scientist, Real-World Evidence will be responsible for evidence generation to support the Paltusotine (Acromegaly) program throughout its lifecycle management, with a particular focus on launch activities. The RWE Scientist will design, implement, and manage RWE studies, including observational studies, claims analyses, chart reviews, survey research and other complementary analyses to support value proposition for Paltusotine. This role will be working directly with our Medical Leads, developing strategies and executing tactics for evidence generation to communicate and present to external stakeholders.

The RWE Scientist will closely collaborate with cross-functional partners including Regulatory, Clinical Research, Clinical Operations, Biometrics, Medical Affairs, Patient Advocacy, and Commercial to successfully incorporate HEOR strategies and evidence generation to support the development and commercialization of our asset in acromegaly. In addition, this role will collaborate externally with academic and/or clinical partners. This position reports into the Senior Vice President, Medical Affairs, with a dotted line reporting into the Vice President, HEOR.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Focus on immediate and short-term (<2 Years) strategic planning horizon
• Provide leadership, career management, coaching and mentoring to others on the team and cross-functionally
• Drive team objectives and goal setting, prioritization, and adherence to plan and strategy
• Develop HEOR research strategies and tactics that support the value proposition for product launches, label expansions, and US market access
• Build value materials to meet evidentiary requirements (i.e. RWE case control studies, literature reviews, chart reviews, patient panel surveys, delphi panels, etc.)
• Perform analysis using real-world large healthcare databases (e.g., insurance claims, electronic health records, retrospective and prospective database analyses)
• Conduct systematic literature search, review and synthesis; review and critique medical and evidence-based outcomes literature & analyses
• Collaborate with internal interdisciplinary teams and external partners to understand and meet needs of key partner evidentiary requirements
• Communicate regularly with internal and external stakeholders to ensure all parties are up to date on the RWE/HEOR information relevant to them, including strategies, and progress
• Strengthen partnerships with stakeholders within the organization and externally with data providers, platform vendors, healthcare providers, payers, FDA etc.
• Collaborate with researchers and expert contributors to assess and recommend data opportunities; lead data strategy working group operations supporting data assessments with functional subject matter experts (SMEs).
• Other duties as assigned

Education and Experience:

Required:

• Advanced degree related to health economics and/or health outcomes research (MSc, MPH, PhD, PharmD, RN, MD)
• Minimum of 10 years of relevant pharmaceutical/ consulting HEOR experience, plus a minimum of 8 years in a supervisory role
• Preferred breadth of experience to include PRO development, statistical analysis, and observational research
• Considerable experience with real-world data, including EMR, claims data, patient charts, survey research
• Ability to impact, influence, and interact with senior business leaders and partners
• Demonstrable success in employing innovative techniques to overcome data limitations
• Excellent analytical skills, including in-depth technical expertise and experience, economic modeling, patient-reported outcome measures and outcomes research methodologies
• Experience of exceptional collaboration with other functions (e.g., biometrics, clinical research, medical affairs, patient advocacy and commercial)
• Possesses excellent communication and interpersonal skills especially over departmental and geographical boundaries
• Ability to lead, collaborate and influence cross-functional teams
• Ensure compliance with corporate policies and procedures, as well as US healthcare laws and regulations
• Flexible, adaptable, diplomatic, and able to effectively deal with ambiguity
• Possesses a good blend of strategic and operational experience with the ability to see the big picture and strong attention to detail

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: $178,000-$222,000

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Vaccination requirement:

Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that allemployees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

Salary Range

The salary range for this position is: $178,000 - $222,000.

Welcome

Thank you for considering Crinetics Pharmaceuticals as your potential employer! We are delighted that you have taken the time to explore opportunities with us.

About Us

Crinetics Pharmaceuticals is a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. We have a prolific discovery engine and robust pipeline across preclinical and clinical development. We are driven by science with a patient-centric and team-oriented culture. Crinetics is a destination for thinkers, doers, and creators, united in a pursuit of innovation in the treatment of endocrine-related conditions . This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Come join our team as we transform the lives of others.