Principal Scientist, Rare Hematologic Malignancies

St. Jude Children's Research Hospital; Memphis (TN); On-site; USD 86,000 - 155,000; Full time

Job summary

St. Jude Children's Research Hospital in Memphis seeks a Scientist in the Elitzur Lab to lead investigations into rare hematologic malignancies, spanning pediatric leukemia and lymphoma.

The work emphasizes genomic, transcriptomic, and functional approaches to define disease mechanisms and identify therapeutic vulnerabilities. The candidate will design and execute experiments, analyze large sequencing and clinical datasets, develop patient-derived models, and contribute to manuscripts and grant

Qualifications

• Ph.D. and/or equivalent research experience in cancer biology, genetics, genomics, molecular biology, or a related field
• Demonstrated experience with genomic and/or transcriptomic analysis (e.g., RNA-seq, WES/WGS, single-cell sequencing)
• Experience working with rare disease cohorts, biobanked samples, or multi-institutional data sharing is a strong plus
• Strong analytical and bioinformatics skills, or willingness to collaborate closely with computational biologists
• Track record of scientific productivity (publications, presentations) appropriate to career stage
• Excellent organizational and communication skills, with the ability to manage multiple concurrent projects
• Experience mentoring trainees is desirable

Responsibilities

• Coordinates research projects and performs laboratory experiments; determines tools or methods required
• Sets up protocols and assists in developing new laboratory techniques
• Identifies data pertinent to analysis; processes, summarizes data, and reports results
• May draft sections of research manuscripts
• Maintains lab operations including equipment maintenance, inventory, and calibrations
• Lead and manage projects focused on molecular characterization of hematologic malignancies
• Design and execute experiments using genomic, transcriptomic, and functional approaches
• Integrate and analyze large-scale sequencing and clinical datasets; collaborate with international consortia
• Establish and maintain patient-derived models for rare subtypes
• Contribute to manuscript preparation and grant writing; present findings at conferences
• Maintain records and ensure compliance for human subjects research
• Instructs staff in basic laboratory techniques
• Maintain regular attendance
• Perform other related duties as assigned

Skills

Genomics analysis

Transcriptomics analysis

Bioinformatics

Scientific communication

Education

PhD or equivalent in cancer biology/genomics

Bachelor's degree in relevant science

Tools

RNA-seq

WES

WGS

Single-cell sequencing

Job description

St. Jude Children's Research Hospital in Memphis seeks a Scientist in the Elitzur Lab to lead investigations into rare hematologic malignancies, spanning pediatric leukemia and lymphoma.

The work emphasizes genomic, transcriptomic, and functional approaches to define disease mechanisms and identify therapeutic vulnerabilities. The candidate will design and execute experiments, analyze large sequencing and clinical datasets, develop patient-derived models, and contribute to manuscripts and grant