Principal Scientist, Pharmacokinetics, Biologics

MSD Malaysia; Boston (MA); On-site; USD 176,000 - 277,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

Retirement benefits (401(k))

Paid holidays and vacation

Job summary

Merck is seeking a Principal Scientist in Boston to lead bioanalytical strategies for biologics within the PDMB group. You will manage a team performing ligand binding assays and MS-based analyses, and collaborate with discovery teams across oncology and immunology portfolios.

The role requires a Ph.D. or equivalent with 6+ years of relevant experience or a Master’s with 10+ years, and involves cross‑functional teamwork, translational PK/PD work, and leadership responsibilities in a fast-paced

Qualifications

• Ph.D. or Master’s with extensive relevant industry/academic experience in biochemistry, chemistry, pharmacology, pharmaceutical sciences or related field.
• Demonstrated leadership in bioanalytical strategies for biologics and related modalities.

Responsibilities

• Lead bioanalytical strategies for biologics and other modalities providing high quality data to discovery teams.
• Manage a team of PDMB scientists developing ligand binding assays and MS-based bioanalysis.
• Serve as project-team SME on multi-modality DMPK activities within oncology and immunology.
• Represent PDMB on cross-functional teams and communicate PK/PD results clearly.

Skills

ADME Bioanalysis

Bioanalytical Method Development

Biologics

Cross‑Functional Teamwork

Drug Development

Drug Discovery Research

Drug Metabolism

Ligand Binding

Pharmaceutical Sciences

Pharmaceutics

Pharmacodynamics

Pharmacokinetics

Pharmacology

PKPD Modeling

Therapeutic Proteins

Education

Ph.D. in Biochemistry/Chemistry/Pharmacology/Pharmaceutical Sciences/ Biomedical Engineering

Master’s degree with 10+ years relevant experience

Tools

Phoenix WinNonlin

Berkeley Madonna

MATLAB

Job description

Job Description Boston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics – Principal Scientist

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating an organization that is inspired by invention and founded on a culture of respect and collaboration.

At our Research & Development Division Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career. The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic-thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s bioanalytical efforts for biologics in our drug discovery portfolio. This position will be based at our research labs in Boston, MA.

The ideal candidate will lead a group focused on bioanalytical efforts (ligand binding assays and mass spectrometry) for biologics and other modalities while also serving as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross‑functional teams through strategic design and evaluation of bioanalytical approaches and results, interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.

Primary Responsibilities

• Lead bioanalytical strategies for a portfolio of drug discovery programs with a primary focus on biologics (monoclonal antibodies, bispecifics, and engineered proteins), providing high quality and timely data to project teams across our Research & Development Division’s drug discovery portfolio
• Manage a team of lab‑based PDMB scientists responsible for developing and executing ligand binding assays and mass spectrometry‑based bioanalytical strategies
• Project‑team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areas
• Contribute to global DMPK strategy through close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates

Education Minimum Requirement

Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience) in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field

Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting

Required Experience and Skills

• Demonstrated experience leading bioanalytical strategies for biologics (ligand binding assays and mass spectrometry), including method development, data generation, interpretation and report writing
• Technical ability to analyze, interpret and provide context around data describing the pharmacokinetic, pharmacodynamic, biomarker or immunogenicity properties of biologics, drug conjugates and peptides
• Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting
• Proven management experience, including mentorship and talent development of multiple direct reports
• Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high‑quality results in a fast‑paced environment

Preferred Experience and Skills

• Hands‑on experience performing translational pharmacokinetic/pharmacodynamic/ efficacy and physiologically‑based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB)
• Proven track record supporting immunology or oncology‑based programs with experience spanning from early discovery through IND‑enabling efforts
• Familiarity with engineering strategies to improve pharmacokinetic and pharmacodynamic properties of protein therapeutics
• Experience working within a research‑driven pharmaceutical company

Required Skills: ADME, Bioanalysis, Bioanalytical Method Development, Biologics, Cross‑Functional Teamwork, Drug Development, Drug Discovery Research, Drug Metabolism, Ligand Binding, Pharmaceutical Sciences, Pharmaceutics, Pharmacodynamics, Pharmacokinetics, Pharmacology, PKPD Modeling, Therapeutic Proteins

Residency Requirements

US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement

The salary range for this role is $176,200.00 - $277,300.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance