Principal Scientist, Peptide Formulation & Developability

Merck & Co.; South San Francisco (CA); On-site; USD 176,000 - 277,000; Full time

Benefits offered by this job

Annual bonus

Long-term incentive

Comprehensive benefits

Job summary

Merck & Co. in South San Francisco, CA is seeking a Principal Scientist in Peptide Formulation (Discovery Pharm Sci) to lead early formulation development and developability assessments for peptide modalities.

You will perform hands-on experiments and drive strategies to optimize candidates with partner functions. You will collaborate across Medicinal Chemistry, DMPK, Nonclinical Safety and Drug Product teams to advance clinical candidates, characterize key physicochemical properties, and mentor

Qualifications

• PhD with at least 6 years of industrial peptide formulation experience.
• Strong communication and leadership skills.
• Experience in preclinical/clinical formulation development and physico-chemical characterization of peptides.
• Experience in candidate selection and developability assessment.

Responsibilities

• Characterize physicochemical properties of peptide molecules and develop deliverable formulations.
• Lead early formulation development and developability assessments for diverse peptide modalities.
• Collaborate with cross-functional teams to select clinical candidates and define delivery approaches.
• Mentor junior scientists and contribute to department scientific initiatives.

Skills

Cell Culture

Process Development

Drug Delivery

Peptides

Pharmaceutical Formulation

Protein Chemistry

Quality by Design

Technology Transfer

Education

PhD in a relevant field

Job description

Merck & Co. in South San Francisco, CA is seeking a Principal Scientist in Peptide Formulation (Discovery Pharm Sci) to lead early formulation development and developability assessments for peptide modalities.

You will perform hands-on experiments and drive strategies to optimize candidates with partner functions. You will collaborate across Medicinal Chemistry, DMPK, Nonclinical Safety and Drug Product teams to advance clinical candidates, characterize key physicochemical properties, and mentor