Principal Scientist – NGS/Genomics and Bioinformatics

ThermoFisher Scientific; Richmond (VA); On-site; USD 130,000 - 160,000; Full time

Benefits offered by this job

Total Rewards package

Employee stock purchase plan (ESPP)

PTO and holidays

Job summary

Thermo Fisher Scientific is seeking a Principal Scientist to lead strategy, design, and implementation of our NGS sequencing platforms in our Richmond, VA lab. The role combines sequencing, proteomics, and spatial transcriptomics to deliver integrated multi-omics solutions.

You will oversee NGS setup, guide genomics/proteomics evaluations, and mentor scientists while partnering with cross-functional teams. A strong leadership track record is expected.

Qualifications

• Lead NGS sequencing platforms strategy and implementation.
• Strong cross-functional leadership and scientific mentorship.
• Expert knowledge of sequencing chemistry, QC, and data analysis.

Responsibilities

• Oversee setup, qualification, and validation of Ultima and Illumina NGS systems.
• Lead evaluation and implementation of genomics and proteomics technologies.
• Define and execute the sequencing strategy for the lab.
• Mentor scientists and analysts in NGS workflows and data interpretation.
• Partner with automation, bioinformatics, and proteomics teams for multi-omics integration.

Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Cleanroom: no hair products, jewelry, makeup, nail polish, perfume, exposed piercings, facial hair etc... allowed, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

This is a fully onsite role based in our bioanalytical laboratory in Richmond, VA. We welcome applicants from all locations within the US. Please note that relocation assistance is not provided for this position, and any relocation costs will be the responsibility of the candidate.

Must be legally authorized to work in the United States withoutsponsorship.

Must be able to pass a comprehensive background check, whichincludes a drug screening.

At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future.

Our PPD Laboratory Services team has a direct impact on improving patient health through the expertise of scientists, industry thought-leaders and therapeutic experts. As the world leader in serving science, our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations.

Discover Impactful Work:

Discover Impactful Work: We are seeking a Principal Scientist to lead the strategy, design, and implementation of our NGS sequencing platforms. This role defines the next phase of our laboratory’s molecular innovation—combining sequencing, proteomics, and spatial transcriptomics to deliver integrated multi-omics solutions.

A Day in the Life:

• Oversee setup, qualification, and validation of the Ultima and/or Illumina NGS system




• Lead evaluation and implementation of genomics and proteomics technologies (NextGen Sequencing (WGS, RNASeq, targeted sequencing), spatial sequencing (10x Genomics Chromium, Visium, Xenium), O-Link HT, NuLISA)




• Define and execute the sequencing strategy for the lab, aligning with organizational and client objectives




• Mentor scientists and analysts in NGS workflows, QC, and data interpretation including bioinformatics support




• Partner with automation, bioinformatics, and proteomics teams for multi-omics integration




• Represent the lab in vendor partnerships, conferences, and technical collaborations

Keys to Success:

• Bachelor's degree or equivalent and relevant formal academic / vocational qualification




• Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 12+ years') or equivalent combination of education, training, and experience.




• OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 10+ year)




• OR PhD and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 8+ year)

Knowledge, Skills and Abilities:

• Demonstrated leadership in launching or managing NGS and spatial sequencing platforms and analysis




• Ultima and/or Illumina NGS - MUST HAVE




• Proven track record of cross-functional scientific leadership and technical innovation




• Expert knowledge of sequencing chemistry, data QC, and assay validation, data analysis/bioinformatics




• Experience integrating sequencing with proteomics or other omics technologies




• Strong communication and external collaboration skills




• Strategic mindset with ability to identify and implement new technologies




• Demonstrated success mentoring staff and building scientific teams

Working Conditions and Environment:

Work is performed in a laboratory and/or a clinical environment with exposure to electrical office equipment.

• Occasional drives to site locations, occasional domestic travel




• Exposure to biological fluids with potential exposure to infectious organisms




• Rare exposure to skin and lung irritants, radiation, toxic materials and hazardous waste




• Personal protective equipment required such as protective eyewear, garments and gloves




• Exposure to fluctuating and/or extreme temperatures on rare occasions

Compensation and Benefits

The salary range estimated for this position based in Virginia is $130,000.00-$160,000.00.

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

• A choice of national medical and dental plans, and a national vision plan, including health incentive programs




• Employee assistance and family support programs, including commuter benefits and tuition reimbursement




• At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy




• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan




• Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.