Principal Scientist - Molecular Biology, Cell Culture Upstream Process Development

BioSpace; Indianapolis (IN); On-site; USD 110,000 - 150,000; Full time

Benefits offered by this job

401(k)

Pension

Vacation benefits

Medical

Dental

Vision

Prescription drug benefits

Flexible spending accounts

Life insurance

Death benefits

Employee assistance program

Fitness benefits

Employee clubs and activities

Company bonus

Job summary

BioSpace is seeking a Principal Scientist responsible for upstream process development including cell line development, process optimization, and robustness studies. The role collaborates with cross-functional teams to support technology transfers.

Candidates should have a BS or MS with 3–6+ years in industry, strong background in cell culture, molecular biology, and recombinant protein expression, and the ability to contribute to regulatory documentation and technical reporting.

Qualifications

• BS or MS degree in a relevant scientific or engineering field with 3–6+ years of industrial experience.
• Strong expertise in cell culture, molecular biology, and recombinant protein expression.
• Ability to work in a team-based laboratory environment.

Responsibilities

• Lead upstream process development activities including cell line development and process optimization.
• Conduct robustness studies and support technology transfers.
• Collaborate with cross-functional teams and author regulatory documentation.

Skills

Molecular biology

Cell culture

Upstream process development

Cell line development

Bioreactor operation

Data science

AI/ML

Recombinant protein expression

Process robustness studies

Technical report writing

Regulatory documentation

Troubleshooting

Statistics

Experimental design

Cross-functional collaboration

Education

BS or MS in a relevant scientific or engineering field

Job description

The Principal Scientist is responsible for upstream process development activities, including cell line development, process optimization, and robustness studies. They will also collaborate with cross-functional teams to support technology transfers and author regulatory documentation.

Requirements

Candidates must hold a BS or MS degree in a relevant scientific or engineering field with 3 to 6+ years of industrial experience. Strong expertise in cell culture, molecular biology, and recombinant protein expression is required, along with the ability to work in a team-based laboratory environment.

Key Skills

• Molecular biology
• Cell culture
• Upstream process development
• Cell line development
• Bioreactor operation
• Data science
• AI/ML
• Recombinant protein expression
• Process robustness studies
• Technical report writing
• Regulatory documentation
• Troubleshooting
• Statistics
• Experimental design
• Cross-functional collaboration

Benefits

• 401(k)
• Pension
• Vacation benefits
• Medical
• Dental
• Vision
• Prescription drug benefits
• Flexible spending accounts
• Life insurance
• Death benefits
• Employee assistance program
• Fitness benefits
• Employee clubs and activities
• Company bonus