Principal Scientist - Modeling & Simulation

Amgen Inc. (IR); Thousand Oaks (CA); On-site; USD 144,000 - 194,000; Full time

Benefits offered by this job

Retirement and Savings Plan

Medical, Dental & Vision coverage

Disability insurance

Flexible Spending Accounts

Stock-based long-term incentives

Job summary

Amgen Inc. in Thousand Oaks, CA, seeks a Principal Scientist in Modeling & Simulation to support clinical pharmacology and translational sciences across therapeutic areas.

You will build PK/PD models, perform advanced statistical analyses, and contribute to dose selection and study design within cross-functional teams, supporting regulatory submissions. The role involves applying state-of-the-art modeling techniques, conducting meta-analyses, and preparing modeling reports.

Qualifications

• PhD/PharmD/MD with 2 years PK/PD or modeling experience; or Master’s with 5 years; or Bachelor’s with 7 years.
• PhD with 3+ years PK/PD or modeling experience preferred.
• Experience in pharmacometric analyses and/or applied biostatistics for small molecules or biologics.

Responsibilities

• Building pharmacostatistical models for PKPD and exposure–response analyses using state-of-the-art techniques.
• Conducting binary, categorical, time-to-event, Poisson, and Bayesian analyses for PK/PD.
• Performing meta-analysis using proprietary and/or literature data.
• Participating in cross-functional teams and providing input for dose selection and study design.
• Generating modeling reports and supporting regulatory submission documents.

Skills

PK/PD modeling

Statistical modeling

Bayesian methods

Binary/Categorical data analysis

MCMC

Cross-functional collaboration

Education

PhD/PharmD/MD

Master's degree

Bachelor's degree

Tools

NONMEM

SAS

R/S-Plus

STAN

MATLAB

Job description

Career Category Scientific Job Description Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas - Oncology, Inflammation, General Medicine, and Rare Disease - we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist - Modeling & Simulation

What you will do

Let’s do this. Let’s change the world. In this vital role you will support Amgen clinical development and translational sciences programs across multiple therapeutic areas as part of the Clinical Pharmacology, Modeling and Simulation department.

Key Responsibilities

• Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.
• Conducting binary, categorical and binary data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.
• Performing meta-analysis using proprietary and/or literature data.
• Participating in cross-functional project teams and providing scientific input for dose selection, early and late study designs using modeling and simulation inputs.
• Contributing to clinical pharmacology strategy for the program(s) and implementing project plans.
• Generating modeling reports and contributing to the summary documents for regulatory submissions.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Principal Scientist we seek is a passionate professional with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience OR Master’s degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience OR Bachelor’s degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Preferred Qualifications

• PhD in pharmaceutical sciences, applied statistics/mathematics, bio-statistics, and/or engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3 years of PK/PD or statistical modeling experience
• 5 + years industry or relevant academic experience in pharmacometric analyses and/or applied bio-statistics of small molecules and/or biologics.
• Proficiency in modeling software (e. g. NONMEM, SAS, R/S-Plus, STAN, MATLAB

What you can expect of us

From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Benefits & Perks

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Salary Range

143,526.75USD -194,183.25 USD

Sponsorship

Sponsorship for this role is not guaranteed.

Equal Opportunity Statement

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Application Deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Other Information

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.