Principal Scientist, Mass Spectrometry

BeOne Medicines Ltd.; San Carlos (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

BeOne Institute in San Carlos, CA, seeks a Principal Scientist to lead cutting-edge mass spectrometry research in drug discovery. You will design and drive programs that translate complex biological questions into actionable insights, advancing emerging therapeutic modalities and screening capabilities.

You will collaborate across biology, chemistry, and technology teams, ensuring robust data and impactful scientific outcomes.

Qualifications

• Ph.D., M.S., or B.S. in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.
• Deep expertise in mass spectrometry, with hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.
• Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows.
• Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
• Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays.
• Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets.
• Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities.
• Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches.
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences.
• Be able to work on-site in San Carlos, CA

Responsibilities

• Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.
• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.
• Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.
• Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.
• Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.
• Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.
• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Skills

Mass spectrometry

LC-MS

Proteomics

Analytical chemistry

Biology

Data analysis

Troubleshooting

Team collaboration

Communication

On-site in San Carlos

Education

Ph.D.

M.S.

B.S.

Tools

Orbitrap

Agilent Q-TOF

MS software

Job description

General Description:

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.


• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.


• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

As a Principal Scientist at BeOne Institute, you will play a key role in conceptualizing, enabling, and driving cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches that expand the frontiers of drug discovery. Working at the interface of biology, chemistry, and technology development, you will help define new ways to interrogate complex biological systems and generate actionable insights that can be translated into transformative medicines. This is a rare opportunity to pursue bold ideas and translate them into real medicines!

Essential Functions of the Job:

• Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities.


• Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.


• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.


• Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.


• Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.


• Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.


• Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.


• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

Supervisory Responsibilities:

• May be a contact for external CRO partners when needed


• May provide matrix or line-function leadership for project teams when needed

Computer Skills:

• Proficiency with mass spectrometry data acquisition, processing, and analysis software.


• Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets.


• Experience with software and tools for MS-based screening and assay development.

Required Qualifications:

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.


• Deep expertise in mass spectrometry, with demonstrated hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.


• Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows.


• Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights


• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.


• Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays.


• Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets


• Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities


• Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches


• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences


• Be able to work on-site in San Carlos, CA

Preferred Qualifications:

• Experience with Orbitrap systems (Astral a plus) and Agilent Q-TOFs strongly preferred.


• Knowledge of cancer pathways.


• Experience with ASMS and APMS workflows (in a drug discovery setting a plus).

Travel:

None

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.