Principal Scientist, LNP Drug Product Characterization (Biophysics and Analytics) - Vaccines

卡湯晩; Waltham (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

A leading company in the biopharmaceutical sector is seeking a Principal Scientist for their Drug Product Platform. This role involves leading a team focused on LNP analytics for mRNA vaccines, developing testing strategies, and mentoring junior scientists. Join us to work on innovative vaccine solutions and enjoy comprehensive benefits and opportunities for career growth.

Benefits

Opportunity to work on innovative mRNA vaccines

Career growth and development opportunities

Comprehensive health and wellbeing benefits

Qualifications

• 3+ years of experience in biophysical characterization of lipid nanoparticles.
• Knowledge of nucleic acids and lipid biochemistry.
• Preferred leadership experience.

Responsibilities

• Lead a team for biophysical characterization and analytical needs.
• Develop testing strategies and collaborate on characterization studies.
• Mentor junior scientists and manage analytical operations.

Skills

Leadership

Communication

Problem Solving

Organizational Skills

Education

Ph.D. in Biophysics, Physics, Chemical Engineering, or related field

Tools

SEC

DLS

HPLC

Microscopy

Job description

Job title

: Principal Scientist, LNP Drug Product Characterization (Biophysics and Analytical) - Vaccines

Location:

Waltham, MA

About the role

As the Principal Scientist within the Drug Product Platform and Early Clinical Development Team, you will provide hands-on leadership to a small team focusing on LNP analytics to characterize LNP Drug Products. Your responsibilities include method transfer, team development, cross-functional collaboration, and supporting the development of new LNP formulations for mRNA vaccines.

Main Responsibilities:

1. Build and lead a team (1-2 contractors) for biophysical characterization and analytical needs.
2. Coordinate with Analytical Science to ensure method alignment and improvements.
3. Develop testing strategies, including sample tracking and data reporting.
4. Collaborate on biophysical characterization studies to support new LNP platform development.
5. Mentor junior scientists and manage analytical operations.
6. Provide scientific insights into particle size, zeta potential, morphology, and other biophysical properties.
7. Support technology transfer to toxicology and pilot scale.
8. Participate in cross-functional teams for mRNA vaccine development.
9. Analyze data, prepare reports, and stay current with literature.
10. Recommend equipment and provide training and guidance to team members.

Qualifications:

• Ph.D. in Biophysics, Physics, Chemical Engineering, or related field with 3+ years of experience.
• Knowledge of nucleic acids, lipid biochemistry, and drug product process development.
• Experience with biophysical characterization of lipid nanoparticles.
• Proficiency with analytical tools like SEC, DLS, HPLC, microscopy, etc.
• Leadership experience is preferred.
• Strong communication, organizational, and problem-solving skills.

Why Join Us?

• Opportunity to work on innovative mRNA vaccines.
• Career growth and development opportunities.
• Comprehensive health and wellbeing benefits.

Sanofi is an Equal Opportunity employer committed to diversity and inclusion. We welcome all qualified applicants to apply.