Principal Scientist, Integrated Computational and Experimental Inflammation Discovery

Amgen SA; South San Francisco (CA); On-site; USD 180,000 - 250,000; Full time

Benefits offered by this job

Flexible work models

Job summary

Amgen in South San Francisco, CA seeks a Principal Scientist to advance integrated computational and experimental inflammation discovery. You will combine wet-lab biology with AI/ML-driven approaches to accelerate therapeutic insights and drive translational programs.

In this role, you will design studies, generate high-quality data, and interpret findings across literature, genetics, and clinical observations.

Qualifications

• Experience collaborating in matrixed research environments.
• Ability to balance scientific rigor with urgency and adaptability.
• Commitment to teamwork, knowledge sharing, and continuous improvement.

Responsibilities

• Continuously apply AI-driven approaches to generate mechanistic insights and refine therapeutic hypotheses.
• Design, execute, analyze, and interpret studies to investigate disease mechanisms.
• Generate high-quality experimental data to support target identification and validation.
• Integrate experimental findings with literature, human genetics, and clinical observations.
• Participate in scientific discussions, target reviews, and portfolio evaluations with data-driven insights.
• Present scientific findings and recommendations to project teams and governance forums.
• Maintain accurate documentation and contribute to organizational knowledge-sharing.
• Embrace a culture of scientific curiosity, collaboration, and continuous learning.

Skills

Collaborative work style

Matrixed team experience

Scientific rigor

Adaptability

Teamwork

Education

PhD (or MD/PharmD) in a relevant field

Master’s degree with 5+ years in Inflammation/Immunology

Bachelor’s degree with 7+ years in Inflammation/Immunology

Job description

Join Amgen's Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist, Integrated Computational and Experimental Inflammation Discovery

What you will do

Let’s do this. Let’s change the world. In this vital role you will combine experimental and computational strategies to accelerate discovery and development of innovative therapies. You will bring deep expertise across wet-lab biology and AI/ML-driven computational and agentic research approaches, enabling human-data-driven understanding of disease mechanisms and therapeutic opportunities.

Key Responsibilities

• Continuously apply computational, agentic and other AI-driven approaches to generate mechanistic insights, refine therapeutic hypotheses, and guide experimental design.
• Design, execute, analyze, and interpret studies to investigate disease mechanisms and test therapeutic hypotheses.
• Generate high-quality experimental data to support target identification, validation, and progression of Inflammation research programs.
• Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making.
• Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations.
• Present scientific findings and recommendations to project teams, governance forums, and departmental meetings.
• Maintain accurate documentation and contribute to organizational knowledge-sharing efforts.
• Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Principal Scientist we seek is a Researcher with these qualifications.

Basic Qualifications:

Doctorate degree PhD

OR

PharmD

OR

MD [and relevant post-doc where applicable] and 2 years of Industry experience in Inflammation/Immunology research

OR

Master’s degree and 5 years of Industry experience in Inflammation/Immunology research

Bachelor’s degree and 7 years of Industry experience in Inflammation/Immunology research

Preferred Qualifications:

• Experience working effectively within highly collaborative and matrixed research environments.
• Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment.
• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen anticipates accepting applications until July 31st; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.