Principal Scientist, Downstream Process Innovation

Catalent; Madison (WI); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Day-one medical coverage

401(k) with match

Tuition reimbursement

Paid time off

Job summary

Catalent is seeking a Principal Scientist in Process Development – Downstream to lead upstream/downstream activities for biologics programs at our Madison site. The role blends scientific leadership with client-facing project management, overseeing downstream processes across mAbs, multispecifics, and proteins.

Responsibilities include guiding chromatography, UF/DF, filtration, and viral clearance while driving technology transfer and cGMP readiness.

Qualifications

• Ph.D. or advanced degree with extensive biologics development experience.
• Strong track record in downstream development of mAbs and proteins.
• Proven leadership of technical programs and client-facing activities.

Responsibilities

• Provide scientific leadership for downstream program strategy and execution.
• Design and optimize chromatography, UF/DF, viral clearance and filtration steps.
• Lead technology transfer and scale-up for cGMP manufacturing readiness.
• Partner with clients to align technical execution with program goals.
• Mentor scientists and cross-functional teams toward project milestones.
• Ensure GDP-compliant documentation and regulatory readiness.

Skills

Scientific leadership

Client-facing

Project management

Education

Ph.D. in Biotechnology or related

M.S. in a relevant field

B.S. in a relevant field

Tools

Chromatography

UF/DF

Filtration

Viral clearance

Cell removal

Job description

Catalent is seeking a Principal Scientist in Process Development – Downstream to lead upstream/downstream activities for biologics programs at our Madison site. The role blends scientific leadership with client-facing project management, overseeing downstream processes across mAbs, multispecifics, and proteins.

Responsibilities include guiding chromatography, UF/DF, filtration, and viral clearance while driving technology transfer and cGMP readiness.