Principal Scientist/Director, DMPK

GondolaBio; San Francisco (CA); On-site; USD 220,000 - 260,000; Full time

Job summary

GondolaBio is seeking a Principal Scientist/Director in DMPK to drive drug development strategies focused on genetic diseases. This role involves collaboration on cross-functional teams and requires expertise in pharmacokinetics and drug metabolism. Successful candidates will see rapid career advancement in a patient-centered organization that prioritizes innovation and ethical standards.

Benefits

Flexible PTO

Market-competitive compensation & benefits package

Access to learning and development resources

Qualifications

• 3-6 years of relevant industry experience.
• Strong understanding of DMPK and drug development.
• Hands-on experience with pharmacokinetic data analysis software.

Responsibilities

• Serve as DMPK representative on drug discovery teams.
• Develop and drive DMPK strategies for candidate selection.
• Design and interpret DMPK studies.

Skills

DMPK principles

Drug metabolism

Problem-solving

Interpersonal skills

Education

PhD or Pharm D in Pharmacokinetics or Pharmaceutical Sciences

Tools

Phoenix WinNonlin

Job description

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This range is provided by GondolaBio. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$220,000.00/yr - $260,000.00/yr

About Gondola Bio:

GondolaBio is a collection of biopharmaceutical companies focused on developing next-generation therapeutics for genetic diseases. Originally carved out of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Neurofibromatosis Type 1 (NF1), a genetic condition where tumors grow on the nerves and skin, is the focus of a pre-clinical stage program in GondolaBio’s portfolio. NF1 affects multiple organ systems, with a wide range of manifestations ranging from neurofibromas (benign nerve sheath tumors) that carry the risk of malignant transformation, to learning difficulties and bone abnormalities. Despite having two FDA-approved MEK inhibitors for NF1 patients, there is still a huge unmet need in providing safer and more efficacious treatment options to the NF1 patients, and GondolaBio strives to address this gap.

Who You Are:

The primary responsibilities of this position are to serve as a DMPK representative on multi-disciplinary drug discovery teams, provide guidance and support to project teams for candidate selection, and further characterize the pharmacokinetic and drug metabolism properties of molecules through early development to IND. This individual will have the opportunity to be exposed to a broad spectrum of therapeutic areas across the portfolio.

Responsibilities:

• Work closely with cross-functional project team members. Participate as a functional representative on the NF1 project team
• Provide guidance on discovery project teams for candidate selection, develop and drive DMPK strategies for lead optimization, and solve ADME-related issues
• Design, coordinate, and interpret in vitro and in vivo DMPK studies
• Determine PK parameters for nonclinical studies using Phoenix WinNonlin and assist with the application of modeling approaches (PK, PKPD) to support human PK and dose predictions
• Support GLP toxicology studies, review toxicokinetic reports, and monitor regulated bioanalysis
• Monitor bioanalytical method development, validation, sample analysis, and review/approve reports
• Generate, analyze and present data, both orally and as written reports
• Potential to work across multiple discovery programs

No matter your role at GondolaBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements:

• PhD or Pharm D. in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on small molecule pharmacokinetics and metabolism with at least 3-6 years of relevant industry experience
• Strong understanding of DMPK principles and drug development processes
• Expertise in drug metabolism is desirable
• Hands-on experience using pharmacokinetic data analysis software such as Phoenix WinNonlin
• Able to work independently and possess excellent interpersonal skills
• Possess effective problem-solving, oral, and written communication skills

What We Offer:

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion

At GondolaBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. GondolaBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Seniority level

• Seniority level

  Director

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science

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