Principal Scientist, Diagnostics

Scorpion Therapeutics; United States; On-site; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics is seeking a senior leader to define and execute diagnostic strategies for oncology programs, aligning biomarker objectives with clinical development plans and portfolio strategy.

You will lead cross-functional teams, coordinate with external partners and Central Labs, and oversee regulatory activities to meet program timelines and objectives across global regions. Strong publication record and IP awareness are highly valued.

Qualifications

• Experience shaping oncology diagnostic strategies.
• Familiar with IHC, NGS, flow cytometry and digital pathology.
• Ability to design studies and align regulatory, clinical, and commercial timelines.
• Strong scientific leadership, collaboration, and meticulous record keeping.
• Publication history and IP/contracting awareness is a plus.

Responsibilities

• Lead cross-functional teams in developing diagnostic strategies across programs.
• Represent diagnostics on global program teams and drive timelines.
• Oversee integrated diagnostic project plans with internal and external partners.
• Work in a fast-paced matrix environment coordinating resources.

Skills

Oncology diagnostics

Biomarker strategies

Cross-functional leadership

Scientific communication

Regulatory/timeline integration

Education

BA/BS

MA/MS

MD/PhD

Tools

IHC

NGS

Flow cytometry

Digital pathology

Job description

Essential Duties and Job Functions

• Define diagnostic strategies for individual oncology programs, aligning biomarker objectives, clinical development plans, and broader portfolio diagnostic strategies in partnership with key cross-functional stakeholders.
• Develop and oversee integrated diagnostic project plans, coordinating internal teams and external partners to ensure resourcing, budgets, regulatory activities, CRO support, and operational execution to meet program objectives and timelines.
• Lead Diagnostic Sub Teams to execute diagnostic strategy from inception through regulatory approval, leveraging cross-functional expertise, third-party diagnostic partners, and central laboratories across global regions.
• Provide diagnostic subject matter expertise to multidisciplinary drug development teams.

Responsibilities

• Reporting to the Head of Oncology Diagnostics within the Diagnostics Group and participate as a member of relevant cross-functional drug development teams.
• Represent the diagnostic function on multiple global program teams to integrate diagnostic considerations into strategy and timelines.
• Lead Diagnostic Sub Teams and co-lead diagnostic partner teams to execute diagnostic strategy across multiple oncology programs.
• Develop, articulate, and manage integrated diagnostic project plans with biomarker, regulatory, clinical development, clinical operations, quality, and external partners.
• Work independently in a fast-paced matrix environment to align stakeholders, marshal resources, and integrate diagnostic development into broader drug development.

Skills / Qualifications

• Demonstrated ability to develop oncology diagnostic strategies aligning biomarker hypotheses, clinical objectives, assay requirements, and patient-selection needs.
• Knowledge of diagnostic platforms including IHC, NGS, flow cytometry, and digital pathology.
• Knowledge of clinical study design and diagnostic regulatory requirements; integrate diagnostic, clinical, regulatory, and commercial timelines across global development/lifecycle.
• Scientific leadership, communication, collaboration; detail-oriented with strong record keeping; independent, flexible self-starter.
• Proven publication record; understanding of IP and contracting terms desired.

Experience

• 10+ years with BA/BS, 8+ years with MA/MS, or 2+ years with MD or PhD; diagnostic strategy/assay development experience supporting oncology drug development preferred.