Principal Scientist, Data Science (Data Products, Integration & Analysis)

Johnson and Johnson; United States; On-site; USD 170,000 - 240,000; Full time

Job summary

Johnson & Johnson is seeking a Principal Scientific Data Scientist to lead the design, implementation, and evolution of AI-ready data products for drug discovery and development. You will build scalable data products that connect discovery through real-world evidence and enable knowledge graphs, semantic reasoning, and GraphRAG across cross-functional teams.

The role requires a strong background in data architecture, cloud platforms, and data governance, with collaboration across scientists, AI

Qualifications

• Requires advanced degree in a relevant field and 5+ years in scientific data engineering or life sciences informatics.
• Experience delivering enterprise-scale scientific data products and data architectures.

Responsibilities

• Lead design and implementation of scalable scientific data products and integration strategies.
• Define data architecture and metadata framework supporting AI-ready assets.
• Architect interoperability across discovery, preclinical, clinical, safety, and real-world data.
• Drive AWS-based platform strategy and scalable data pipelines with platform teams.
• Collaborate with scientists, data strategists, and AI engineers to deliver data solutions.
• Ensure governance, security, and FAIR data principles across products.

Skills

Data architecture

Cloud-native platforms

Metadata management

Data governance

Predictive modeling

Python / R

Knowledge graphs

GraphRAG

AI readiness

Cross-functional collaboration

Education

Master's or PhD in Computer Science

Data Engineering or Biomedical informatics

Information systems or Computational biology

Tools

AWS-based data platforms

Data lakes / lakehouses

Data catalogs and lineage solutions

APIs / data services

Job description

Principal Scientific Data Scientist

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

The Principal Scientific Data Scientist will lead the design, implementation, and evolution of scientific data products and integration strategies supporting AI-enabled drug discovery and development.

This individual will be responsible for creating scalable, interoperable, and AI-ready data products that connect discovery, preclinical, clinical, safety, and real-world evidence domains, and enable the creation of validated-biomarker data assets. The role will establish the data architecture, integration strategy, metadata framework, and productization approach needed to support semantic reasoning, knowledge graphs, GraphRAG, advanced analytics, and agentic AI applications.

Working closely with scientific stakeholders, knowledge architects, AI engineers, and Amazon BioDiscovery platform teams, this individual will define the future-state scientific data ecosystem and ensure high-quality data products are delivered to support translational science and patient safety initiatives.

Build AI reasoning models to support data-driven translational safety decision making.

Mission: Build and operationalize AI-ready scientific data products that enable seamless integration, harmonization, and reuse of data across the drug discovery and development lifecycle.

Key Responsibilities:

• Scientific Data Product Strategy
• Define and execute a scientific data product strategy supporting:
• Discovery Research
• Translational Science
• Preclinical Safety
• Clinical Development
• Pharmacovigilance
• Real-World Evidence
• Establish reusable, scalable data products that support analytics, AI, knowledge graph, and scientific reasoning use cases.
• Develop product roadmaps aligned with organizational priorities and scientific objectives.
• Data Integration Architecture
• Design integration frameworks connecting heterogeneous scientific data sources.
• Define data harmonization strategies spanning:
• SEND
• SDTM
• ADaM
• MedDRA
• Imaging
• Omics
• Biomarker
• Pathology
• Real-world data
• Create architecture patterns supporting cross-domain data interoperability.
• Digital Platform Leadership
• Define the implementation strategy for scientific data products deployed on AWS
• Partner with Amazon engineering and deployed platform resources to deliver scalable data pipelines and data products.
• Provide technical leadership and architectural oversight for implementation activities aligned recommendations from the Data Strategy group.
• Ensure digital solutions align with enterprise architecture, security, governance, and AI-readiness requirements.
• Data Product Development
• In collaboration with Data Strategy group, lead design and implementation of:
• Curated datasets
• Semantic-ready data products
• Feature stores
• Metadata products
• Scientific data services
• AI-ready data assets
• Establish reusable patterns for data onboarding, transformation, validation, and publication.
• Data Quality & Metadata
• Define metadata standards and data quality frameworks.
• Implement lineage, provenance, traceability, and FAIR data principles.
• Establish monitoring and quality controls for scientific data products.
• Data Analysis:
• Build predictive AIML models to support translational safety decision making.
• Stakeholder Engagement
• Partner with:
• Discovery Scientists
• Toxicologists
• Clinical Scientists
• Safety Scientists
• Data Scientists and Data Strategy business partners.
• Knowledge Architects
• AI Engineers
• Translate scientific questions into scalable data products and technical solutions.

Required Qualifications:

• Education
• Master's or PhD in:
• Computer Science
• Data Engineering
• Bioinformatics
• Biomedical Informatics
• Information Systems
• Computational Biology
• Related scientific discipline
• Experience
• 5+ years of experience in scientific data engineering, data architecture, data products, or life sciences informatics.
• Demonstrated experience designing and delivering enterprise-scale scientific data products.
• Technical Expertise
• Strong expertise in:
• Data architecture
• Data modeling
• Data product design
• Cloud-native data platforms
• Metadata management
• Data governance
• Predictive model development
• Experience with:
• AWS-based data platforms
• Data lakes and lakehouses
• Distributed data processing
• APIs and data services
• Data cataloging and lineage solutions
• Scientific Data Standards
• Strong familiarity with:
• SEND
• SDTM
• ADaM
• MedDRA
• Preferred familiarity with:
• FHIR
• OMOP
• DICOM
• Biomarker and omics data standards

Preferred Qualifications:

• Experience supporting knowledge graphs, semantic architectures, or GraphRAG initiatives.
• Experience building AI-ready data products and feature stores.
• Familiarity with ontology-driven data integration approaches.
• Experience partnering with cloud providers or external platform teams.
• Experience operating in highly regulated scientific environments.

Leadership Competencies:

• Strategic thinker capable of defining long-term data product roadmaps.
• Strong communicator who can bridge scientific and technical communities.
• Ability to influence cross-functional teams without direct authority.
• Strong execution focus with a bias toward scalable, reusable solutions.
• Passion for transforming biomedical R&D through data, AI, and modern engineering practices.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or

Tagged as: Life Sciences