Principal Scientist, Cardiovascular Translational Biomarker

Scorpion Therapeutics; Princeton (NJ); On-site; USD 150,000 - 200,000; Full time

Benefits offered by this job

Health coverage (medical/pharmacy/dent

Wellbeing support

401(k)

Disability and life insurance

Paid time off

Job summary

Scorpion Therapeutics is seeking a translational scientist with cardiovascular biology to identify biomarkers supporting late discovery programs toward early clinical trials. On-site lab environment; collaborate across development teams to establish PD endpoints and test hypotheses using human samples or relevant systems.

The role emphasizes biomarker discovery, expert lab work (cell culture, ELISA, IHC, qPCR), and leadership in studies from design to publication, with opportunity to train

Qualifications

• 8+ years of experience with a Bachelor's degree, 6+ years with a Master's, or 4+ years with a PhD in relevant fields.

Responsibilities

• Define pharmacodynamic biomarkers of response and disease progression; explain clinical translation.
• Design experiments; perform/interpret lab work (cell culture, immunoassays ELISA/MSD, IHC, protein signaling, qPCR).
• Make in-life experimental modifications as needed.
• Lead studies to completion; analyze samples internally or direct CRO studies.
• Critically evaluate programs; present findings/recommendations.
• Document and present data in a timely manner; collaborate cross-functionally.
• Train and guide team members.
• Author reports/abstracts/publications.

Skills

Cardiovascular physiology

Preclinical/clinical methodologies

Imaging biomarkers

iPSC-CM/engineered heart tissue

Lab leadership / project coordination

Attention to detail

Rodent handling

Cell culture

Tools

ELISA

MSD

IHC

qPCR

Job description

Position Summary

Translational scientist with cardiovascular biology background to identify and discover biomarkers supporting progression of late-discovery programs to early phase clinical trials. Collaborate with development; may serve as discovery-to-development liaison. Establish pharmacodynamic endpoints consistent with mechanism of action using in vivo/functional-structural analyses and ex vivo/in vitro biochemical or molecular assays (including novel assay development). Test translational hypotheses using human samples or human-relevant systems; primarily on-site, lab-based.

Position Responsibilities

• Define pharmacodynamic biomarkers of response and disease progression; explain clinical translation.
• Design experiments; perform/interpret lab work (cell culture, immunoassays ELISA/MSD, IHC, protein signaling, qPCR).
• Make in-life experimental modifications as needed.
• Lead studies to completion; analyze samples internally or direct CRO studies.
• Critically evaluate programs; present findings/recommendations.
• Document and present data in a timely manner; collaborate cross-functionally.
• Train and guide team members.
• Author reports/abstracts/publications.

Basic Qualifications

• Bachelor's: 8+ years (academic/industry) OR Master's: 6+ years OR Ph.D.: 4+ years.

Preferred Qualifications/Skills

• Strong cardiovascular physiology and preclinical/clinical methodologies; imaging biomarkers (e.g., ultrasound-echocardiography, MRI, PET).
• Apply 3Rs; species-specific animal research considerations.
• Rodent handling experience.
• iPSC-CM/primary cardiac cell/engineered heart tissue expertise.
• Excellent, accurate/reproducible lab skills; manage external collaborators; self-motivated, detail-oriented, collaborative.

Benefits (explicit)

• Health coverage (medical/pharmacy/dental/vision); wellbeing support; 401(k); disability and life insurance.
• Paid time off includes flexible/unlimited time off for US exempt employees and other vacation/holiday options depending on location.