Principal Scientist, Translational Medicine, Neuroscience

Jobtailor; New Jersey; On-site; USD 210,000 - 290,000; Full time

Job summary

Jobtailor in the United States is seeking a physician-scientist with an MD or MD/PhD to lead early clinical development in neuro-psychiatric targets and biomarker strategies.

You will design and oversee translational studies across preclinical and Phase I–II trials, collaborating with discovery sciences, pharmacology, regulatory affairs, and global trials teams to drive regulatory filing support and cross-functional development initiatives.

Qualifications

• Doctoral degree in medicine or MD/PhD required.
• Clinical board certification in Neurology or Psychiatry preferred.
• Translational research and early clinical development experience helpful.
• Must reside in United States or Puerto Rico; visa sponsorship: No.

Responsibilities

• Lead early clinical development strategy from preclinical to Phase 1/2 proof-of-concept.
• Design and execute clinical pharmacology studies and biomarker validation.
• Collaborate with discovery sciences, pharmacology, regulatory affairs, and global trials teams.
• Develop and execute regulatory filing support and presentations.

Skills

Clinical Trial Design

Translational Research

Drug-Drug Interaction Studies

Experimental Medicine Studies

Regulatory Filing Support

Blood/Tissue Sampling

Imaging Techniques

Wearable Devices

Behavioral Responses

Education

Doctoral Degree (MD or MD/PhD)

Clinical Board Certification in Neurology or Psychiatry

Job description

• Work with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets
• Design preclinical and clinical experiments to validate targets and/or pathways and leverage this work for development of novel therapeutics
• Collaborate with discovery scientists, pharmacologists, toxicologists, and other specialists to advance therapeutics from preclinical into clinical development
• Lead early development teams and collaborate with internal and external staff across discovery research, biostatistics, drug metabolism, modeling and simulation, regulatory affairs, and global clinical trials operations
• Develop and execute clinical pharmacology studies in Phases I–IV, including formulation or device changes, drug-drug interaction studies, and special-population studies
• Provide early-phase and clinical pharmacology support through regulatory filing, including preparation of supporting documents and presentations
• Develop and execute studies to validate clinical biomarkers using blood/tissue sampling, imaging, electrophysiological methods, wearable devices, and behavioral responses
• Assess internal and external partnership opportunities using clinical and scientific expertise
• Engage with scientific and academic thought leaders through consultations, posters, publications, and conference attendance/presentations
• Work with key functions across the company at research sites around the world
• Contribute to novel target identification and validation with Discovery Sciences
• Lead early clinical development strategy from preclinical development through Phase 1 and Phase 2 proof-of-concept studies
• Develop biomarker strategies and experimental medicine studies from First-in-Human studies through clinical Proof-of-Concept
• Develop and execute clinical pharmacology strategies supporting later development and worldwide regulatory applications

Requirements

• Doctoral degree: MD or MD/PhD (or international equivalent) required
• Experience in biomedical research, with a demonstrated record of scientific scholarship and achievement including scientific publications
• Strong interpersonal, writing, and presentation skills
• Ability to function in a team environment
• Experience in clinical medicine including completion or anticipated completion of residency training is required
• Training and clinical board certification or eligibility in Neurology, Psychiatry or a related discipline involving care of neurologic/psychiatric diseases preferred
• Experience as an academic faculty member preferred
• Prior experience in translational research and/or early clinical development helpful but not required
• Must reside in the United States or Puerto Rico
• Visa sponsorship: No
• 10% travel required

Core Competencies

Demonstrates expertise in clinical pharmacology and early clinical development, with a focus on designing and executing studies that validate novel therapeutic targets and biomarkers. Engages effectively with cross-functional teams and thought leaders to advance drug development from preclinical to clinical phases.

Highest-signal resume keywords

• Clinical Pharmacology Studies
• Early Clinical Development Strategy
• Biomarker Validation
• Interpersonal Skills
• Scientific Publications

ATS Optimization Keywords

Hard Skills

• Clinical Trial Design
• Translational Research
• Drug-Drug Interaction Studies
• Experimental Medicine Studies
• Regulatory Filing Support
• Blood/Tissue Sampling
• Imaging Techniques
• Electrophysiological Methods
• Wearable Devices
• Behavioral Responses

Soft Skills

• Team Collaboration
• Writing Skills
• Presentation Skills

Certifications & Qualifications

• Doctoral Degree (MD or MD/PhD)
• Clinical Board Certification in Neurology or Psychiatry

Industry Keywords

• Biomedical Research
• Novel Therapeutics
• Clinical Development
• Proof-of-Concept Studies
• Regulatory Affairs
• Global Clinical Trials Operations
• Discovery Sciences
• Scientific Scholarship
• Academic Faculty Experience
• Neurologic/Psychiatric Diseases