Principal Scientist, Biologics Optimization

Johnson & Johnson Innovative Medicine; North Carolina; On-site; USD 140,000 - 210,000; Full time

Job summary

Johnson & Johnson Innovative Medicine seeks a Principal Scientist, Biologics Optimization in Spring House, PA to lead optimization across programs, translating biology into engineered antibodies with improved function. You will guide strategy using sequence, structure and developability insights, leveraging AI/ML tools and collaborating with therapeutic area scientists.

The role emphasizes scientific leadership, cross-functional influence, and the translation of ideas into actionable

Qualifications

• MS degree in molecular biology, biochemistry, biotechnology or related field; PhD preferred.
• 3+ years of industry experience in biologics discovery or protein engineering.
• Strong leadership and collaboration across multidisciplinary teams.
• Expertise in antibody design, developability, and structure-function relationships.
• Experience applying AI/ML or computational biology to design optimization.
• Excellent written and verbal communication for publications and reviews.

Responsibilities

• Lead biologics optimization efforts across multiple programs with rational design.
• Serve as SME in function-driven optimization and novel development initiatives.
• Develop strategies integrating sequence, structure, developability and function.
• Lead project teams, manage timelines, and ensure progress on portfolio projects.
• Collaborate with TD/TA to define hypotheses and screening cascades.
• Apply AI/ML and data-driven approaches to guide design and hit selection.
• Present findings to multi-functional teams and draft patents/manuscripts.

Skills

Biologics optimization

Antibody engineering

Protein engineering

AI/ML in biology

Leadership

Cross-functional collaboration

Scientific writing

Communication

Education

MS in Molecular Biology / Biochemistry / Biotechnology

PhD preferred

Tools

Python

Schrödinger

MOE

PyMOL

Chimera

AlphaFold workflows

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Principal Scientist, Biologics Optimization in Spring House, PA

Purpose: The Biologics Optimization team within Biologics Discovery is responsible for the design and optimization of lead biologic variants across multiple therapeutic modalities to achieve differentiated functional outcomes aligned with desired therapeutic mechanism of action (MoA). In this position, the Principal Scientist will serve as a scientific leader and subject matter expert in biologics optimization, driving and dissecting protein engineering strategies that translate molecular design into improved biological function across diverse therapeutic modalities. This role requires deepexpertisein antibody and protein engineering, computational and AI/ML-enabled design approaches, and mechanism-drivenbiologicsdiscovery expertise. The successful candidate will partner closely with Therapeutic Area scientists, computational scientists, protein engineers, and drug discovery teams to develop and implement optimization strategies that enhance potency, selectivity, efficacy, and overall therapeutic performance.

The Principal Scientist will be expected toestablishand champion scientific best practices in function-driven optimization,leveragingdetailed understanding of antibody structure-function relationships, protein sequence space, and biological pathways to guide engineering decisions. This role offers the opportunity to influence discovery programs across the portfolio while shaping future optimization capabilities and technologies within Biologics Discovery. This role offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but to develop new processes and technologies in collaboration with other functional group with the opportunity to lead project teams and interact with world-class Therapeutic Area scientists.

You will be responsible for:

• Lead biologics optimization efforts across multiple therapeutic programs, translating target biology and desired mechanisms of action into rational protein engineering strategies.
• Serve as a subject matter expert in function-driven optimization: develop and champion novel development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Develop optimization strategies that integrate antibody sequence, structure, developability, and biological function to achieve programobjectives.
• Lead/participate on project teams to advance discovery portfolio projects. Act as a point of accountability for optimization engineering asks and manage project timelines independently.
• Partner with teams across TD/TA to define critical functional hypotheses andestablishscreening cascades that enableMoA-driven decision making.
• Apply computational, AI/ML, and data-driven approaches to guide variant design, library construction, sequence prioritization, and hit selection.
• Evaluate emerging technologies and develop innovative approaches to acceleratebiologicsoptimizationworkflows and therapeutic discovery.
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc.

Qualifications / Requirements:

• Education: A minimum of a MS Degree in in Molecular Biology, Biochemistry, Biotechnology, Biomedical Engineering, structural biology or related field is required. PhD is highly preferred.

Skills/Experience

Required:

• A minimum of 3 years of relevant industry experience inbiologicsdiscovery, protein engineering, or therapeutic optimization isrequired.
• Demonstrated scientific leadership andexpertiseinbiologicsoptimization with a strong focus on improving functional outcomes aligned with therapeutic mechanisms of action.
• Extensive experience in antibody and protein engineering with a demonstrated ability to advance therapeutic molecules through optimization cycles.
• Deep understanding of antibody structure-function relationships, including variable region architecture, framework and CDR design, sequence liabilities, affinity maturation, specificity engineering, and developability considerations.
• Strong understanding of probing therapeutic biology anddemonstratedexperience applying biological insights to address function-driven engineering challenges in wet-lab setting.
• Proven ability to evaluate therapeutic mechanisms of action and design optimization strategies that improve biological activity, efficacy, selectivity, or target engagement.
• Strong understanding of biophysical and biochemical methods used for antibody and protein characterization, including techniques such as SPR, ELISA, flow cytometry, thermal stability analysis, aggregation assessment, and other developability metrics.
• ExperienceleveragingAI/ML, computational biology, protein modeling, or data science approaches to supportbiologicsoptimization and engineering workflows.
• Zeal for addressing complex scientific questions and solving novel challenges with creativity and a collaborative spirit. Demonstration of successful implementation of new ideas with calculated risk taking. Abilities to lead by influence and communicate across teams with diverse backgrounds is required.
• Demonstration of clear, concise, and timely communication skills, exemplified by peer-reviewed publications is required.

Preferred:

• Candidates with a Master’s degree: 6 years of industry experience is preferred
• Candidates with a PhD: 3 years of industry experience is preferred
• Expertise in scientific computing (e.g. Python) and experience with in silico protein structure and sequence modeling using AI/ML methods to facilitate collaboration with computational and AI/ML functional teams
• Expertisein protein structure modeling and visualization tools such as Schrödinger, MOE,PyMOL, Chimera, or AlphaFold-based workflows.
• Experience with cell-based functional assays across oncology or immunology areas (e.g. T-cell redirection, immune modulation)
• Experience with display-based technologies for protein engineering and optimization, with preference for yeast display and/or mammalian display platforms.
• Experience/strong understanding of high-throughput binding assays and screening technologies, including ELISA, SPR, MSD, flow cytometry, or related platforms.
• Strong understanding of mammalian protein expression systems, including transient expression and recombinant protein production workflows.
• Experience integrating large-scale experimental datasets with computational and AI/ML approaches to accelerate optimization decisions.
• Demonstrated ability toestablishnew scientific capabilities, influence strategy, and mentor scientists within a matrixed research environment.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.

Required Skills:

Preferred Skills: