Principal Scientist Bioconjugation

BioSpace; Thousand Oaks (CA); On-site; USD 170,000 - 210,000; Full time

Benefits offered by this job

Stock-based incentives

Comprehensive benefits

Annual bonus program

Time-off programs

Job summary

Amgen in Thousand Oaks, CA, seeks a Principal Scientist to lead bioconjugation process development and industrialization of ADC manufacturing. The role drives technology innovation, mentors staff, and ensures cGMP transfer to CMOs while advancing Amgen's portfolio.

You will oversee process development, modeling, and regulatory support, collaborating across PD and DSTS groups to deliver robust, scalable manufacturing solutions for early to late-stage programs.

Qualifications

• PhD/PharmD/MD with 2 years of scientific experience.
• Masters with 5 years of scientific experience.
• Bachelors with 7 years of scientific experience.

Responsibilities

• Lead multidisciplinary project teams for bioconjugate manufacturing processes.
• Drive bioconjugation technology innovation.
• Support cGMP manufacturing and technology transfer to CMOs.
• Develop strategies to ensure process performance via modeling and characterization.
• Guide successful completion of project deliverables and timelines.
• Coach and mentor staff; collaborate cross-functionally with regulatory teams.
• Stay current in the field of bioconjugation manufacturing.

Skills

Bioconjugation

ADCs

GMP transfer

Leadership

Process development

Education

PhD/PharmD/MD

Masters

Bachelors

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist Bioconjugation

What you will do

Lets do this. Lets change the world. In this vital role you will join Amgens DSTS group within Process Development (PD)which is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets. Process chemists within our team apply their training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

Amgen is currently seeking a talented Principal Scientist who will lead the development of efficient and sustainable manufacturing processes for bioconjugates, including antibody drug conjugates (ADCs), drive technology innovation, provide technical expertise, and develop and mentor staff within the organization. The successful candidate for this role will be experienced in bioconjugation process development and industrialization of bioconjugation manufacturing processes with a proven track record of scientific innovation and leadership within the pharmaceutical industry. The role will be located at our Thousand Oaks, California campus.

Key Responsibilities

• Lead a multidisciplinary project team in the development of sustainable and cost-effective processes for bioconjugate manufacturing at all stages of clinical development
• Drive bioconjugation technology innovation
• Support cGMP manufacturing and technology transfer to GMP production facilities
• Develop strategies to ensure process performance through process understanding, modeling and characterization
• Guide successful completion of project deliverables and ensure timelines are met
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugation manufacturing
• Coach and provide career and scientific / technical advice to colleagues within the organization

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of Scientific experienceOR
• Masters degree and 5 years of Scientific experienceOR
• Bachelors degree and 7 years of Scientific experience

Preferred Qualifications

• Doctoral degree and 4+ years in the pharmaceutical industry with expertise in bioconjugate process development, preferably in Antibody Drug Conjugates (ADCs) with HPAPI linker-payload synthesis experience
• GMP manufacturing and technology transfer to CMOs
• Demonstrated functional representation on a CMC or PDT team
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
• Proven track record of publications, patents and presentations

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Benefits and Compensation

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans

Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Equal Opportunity employer

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.