Principal Scientist, Antibody Engineering

EPM Scientific; San Diego (CA); On-site; USD 160,000 - 180,000; Full time

Job summary

A leading biotechnology company seeks a Principal Scientist specializing in Antibody Engineering in San Diego. The successful candidate will lead innovative protein engineering efforts, oversee teams, and contribute to transforming molecules into therapeutic candidates. Ideal for seasoned professionals with expertise in structural biology and protein sciences, this role promises to be pivotal in advancing treatments for serious health conditions.

Qualifications

• Minimum 5 years relevant industry experience.
• Proficiency in antibody formats including monoclonal antibodies.
• Experience with developing therapeutics.

Responsibilities

• Manage and mentor a team of scientists.
• Lead design and generation of combinatorial libraries.
• Guide integration of data for predictive modeling.

Skills

Protein Structure

Molecular Interactions

Biophysical Characteristics

Protein Engineering

High-Throughput Assay Development

Computational Tools

Education

MS or PhD in Biochemistry, Chemistry, or related field

Job description

Principal Scientist, Antibody Engineering

Principal Scientist, Antibody Engineering

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This range is provided by EPM Scientific. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$160,000.00/yr - $180,000.00/yr

Direct message the job poster from EPM Scientific

Recruitment Consultant – Preclinical Research | Antibody/Protein Engineering + Proteomics

Company Overview

An innovative biotechnology company leveraging synthetic biology to pioneer a novel class of biologic therapeutics. Their focus is on developing transformative treatments for cancer and other serious conditions, with the goal of delivering meaningful outcomes for patients.

Position Summary

The company is looking for a seasoned scientist with a strong background in protein engineering to lead efforts in optimizing early-stage molecules into viable therapeutic candidates. This role requires a blend of technical expertise in structural biology, molecular biology, and protein sciences, along with leadership capabilities to guide a team and collaborate across disciplines. The ideal candidate will play a central role in designing and executing protein engineering strategies and will serve as a scientific advisor across multiple programs.

Primary Responsibilities

• Manage and mentor a team of scientists focused on protein engineering, offering both scientific direction and career development
• Partner with cross-functional teams in discovery, development, and project management to transition molecules from discovery hits to clinical candidates
• Lead the design and generation of combinatorial libraries and oversee engineering campaigns for antibodies and proteins
• Enhance lab operations through continuous workflow improvements
• Guide the integration and interpretation of experimental and computational data to support predictive modeling efforts
• Provide strategic input on therapeutic design, including structural hypotheses, reagent development, and molecular formatting
• Support leadership in shaping technology development initiatives and long-term scientific strategy
  
  

Required Qualifications

• MS or PhD in Biochemistry, Chemistry, or a related field, with a minimum of 5 years of relevant industry experience
• Strong command of protein structure, molecular interactions, and biophysical characteristics
• Expertise in a variety of antibody formats, such as monoclonal antibodies, bispecifics, scFvs, and single-domain antibodies
• Demonstrated experience in engineering therapeutic proteins, including humanization, liability mitigation, and optimization
• Proficiency in evaluating and improving developability attributes like solubility, stability, and manufacturability
• Familiarity with computational tools, databases, and machine learning applications in protein design
• Proven track record of managing and developing scientific talent
  
  

Preferred Experience

• Hands-on experience with high-throughput assay development and plate-based screening
• Background in engineering small proteins or enzymes
• Ability to synthesize and apply structural and biophysical data (e.g., epitope mapping, binding kinetics) to guide design decisions

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research

• Industries

  Pharmaceutical Manufacturing

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