Principal Scientist, Analytical Development - Oligonucleotides & Peptides

Vertex Pharmaceuticals Incorporated; Boston, Auburn (MA, ME); On-site; USD 136,000 - 204,000; Full time

Job summary

An innovative biotechnology company is seeking an analytical project leader to join its dynamic Analytical Development team. This pivotal role involves overseeing analytical deliverables for various therapeutic projects, including small molecules and oligonucleotides. The successful candidate will collaborate with cross-functional teams to ensure effective project management and compliance with regulatory standards. This position offers a unique opportunity to contribute to the development of groundbreaking therapies in a supportive and growth-oriented environment, where your expertise will directly impact patient care and product success.

Benefits

Medical, dental, and vision benefits

Generous paid time off

Educational assistance programs

Student loan repayment

Commuting subsidy

401(k) matching

Annual bonus and equity awards

Qualifications

• 4+ years experience in pharmaceutical industry.
• Expertise in drug substance and product development.

Responsibilities

• Oversee analytical deliverables for clinical projects.
• Develop strategies for drug substance and product development.

Skills

Leadership in pharmaceutical settings

CMC experience

Project management skills

Analytical techniques expertise

Communication skills

Education

Ph.D. in relevant field

Master's degree

Bachelor's degree

Tools

LC-MS

IP-RP-LC

IEX

Sequencing

Peptide mapping

Job description

Job Description

General Summary:

As Vertex continues to expand its pipeline, in our commitment to serving patients, we are offering an exciting opportunity to join our Analytical Development team. We are actively seeking an analytical project leader to support small molecules, oligonucleotides, peptides, and conjugated therapeutics in Boston. This newly created position will be responsible for all aspects of analytical development related to both drug substance and drug product components of their assigned projects. The successful candidate will contribute significantly to advancing a product from the earliest stages of clinical development to marketing approval.

Key Duties and Responsibilities:

• Project Oversight: Oversee all analytical deliverables required to support clinical progression for assigned projects, including IND/IMPD submissions and information requests, as well as represent Analytical Development on cross-functional project teams. Manage analytical activities and timelines internally and externally at CROs/CDMOs.
• Strategy Development: Develop, align, and execute analytical project team plans and strategies to support drug substance and drug product development.
• Collaboration: Collaborate with all CMC functions and CMC leadership to develop strategies and deliver on key objectives; including managing matrixed analytical support of process and formulation activities.
• Technical Leadership: ensure successful method development/validation, release, and stability testing of drug substance and drug product.
• Mentorship: Mentor and train team members on laboratory practices and modality specific analytical techniques.

Knowledge and Skills:

• Demonstrated leadership experience in a pharmaceutical or biotechnology setting.
• CMC experience in pre-clinical and clinical development of small molecules, oligonucleotides, peptides, and/or conjugated therapeutics.
• Exceptional organizational, communication, leadership, and project management skills.
• Strong knowledge and experience with cGMPs and regulatory guidelines.
• Expertise with analytical techniques used in oligonucleotide and peptide therapeutics, such as LC-MS, IP-RP-LC, IEX, sequencing, and peptide mapping.

Education and Experience:

• Ph.D. with 4+ years, Master's degree with 7+ years, or BS degree with 10+ years of relevant experience within the pharmaceutical industry with an expertise in the development of small molecules, oligonucleotides and/or peptides.

Pay Range:

$136,000 - $204,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]