Principal Scientist

Trimaren Human Capital Partners; Watertown (TN); Sur place; USD 180 000 - 240 000; Plein temps

Résumé du poste

Confidential Biotech in Massachusetts is seeking an accomplished leader to establish and head the Cellular Biology function. This role combines strategic science with hands-on execution to shape therapeutic discovery in hematologic diseases.

You will build capabilities, generate mechanistic data, and collaborate across R&D to advance programs toward the clinic, initially dedicating ~50% bench work while the team scales.

Qualifications

• PhD with 8+ years in pharmacology, cell biology, hematology or related field; or MS with 10+ years in biopharma.
• Expert bone marrow biology and hematology background with drug discovery experience.
• Hands-on experience developing cell-based models of hematologic diseases.
• Strong expertise in kinase biology and intracellular signaling.
• Experience with scRNA-seq, ATAC-seq, CUT&RUN and data integration.
• Proven leadership and cross-functional program management.

Responsabilités

• Lead and build the Cellular Biology function with strategy and experimental standards.
• Develop cell-based translational models of hematologic diseases, focusing on bone marrow biology.
• Characterize pharmacodynamic and mechanistic properties of novel therapeutics.
• Identify druggable targets and opportunities addressing unmet hematologic needs.
• Investigate signaling pathways to understand therapeutic response and cellular effects.
• Apply scRNA-seq, ATAC-seq, and CUT&RUN to define cellular states and mechanisms.
• Integrate multi-omic data to guide drug-discovery strategy.
• Develop assays such as flow cytometry, PCR, ELISA and primary-cell culture.
• Support candidate selection and go/no-go decisions for programs.
• Collaborate with CROs and internal teams to enable timely data delivery.

Connaissances

Bone marrow biology

Hematology

Cell-based models

Kinase biology

Signaling pathways

Functional genomics

Epigenomics

scRNA-seq

ATAC-seq

CUT&RUN

Flow cytometry

PCR

ELISA

Cell culture

Formation

PhD in relevant field

MS in relevant field

Description du poste

Confidential Biotech | Stealth Mode | On-Site in MA

We are partnering with a well-capitalized, stealth-stage biotechnology company developing a differentiated therapeutic platform with the potential to address significant unmet medical needs.

We are seeking an accomplished and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate will bring deep scientific and technical expertise in bone marrow biology and hematology, extensive hands-on experience developing cell-based translational models of genetically defined human hematologic diseases, and strong mechanistic expertise in cell signaling, including kinase-driven pathways.

The successful candidate will also bring experience applying advanced functional genomic and epigenomic approaches including scRNA-seq, ATAC-seq, and CUT&RUN to understand disease biology, pharmacodynamic response, and therapeutic mechanism of action.

This individual will serve as both a scientific leader and a hands-on experimentalist, generating decision-enabling data that shape scientific strategy, identify novel therapeutic opportunities, support candidate selection, and advance programs toward and through the clinic.

What You’ll Do

• Lead and build the Cellular Biology function, establishing scientific strategy, experimental capabilities, and rigorous standards for cellular and mechanistic biology.
• Develop and implement cell-based translational models of genetically defined human hematologic diseases, with particular emphasis on bone marrow and hematopoietic biology.
• Design and execute studies that characterize the pharmacodynamic and mechanistic properties of novel therapeutic molecules.
• Apply deep expertise in hematology and bone marrow biology to identify novel druggable targets, therapeutic approaches, and opportunities addressing unmet needs in priority hematologic diseases.
• Investigate kinase-driven and other intracellular signaling pathways to understand target biology, therapeutic response, and downstream cellular effects.
• Apply functional genomic and epigenomic approaches including scRNA-seq, ATAC-seq, and CUT&RUN to characterize cellular states, transcriptional programs, chromatin regulation, and therapeutic mechanisms.
• Integrate cellular, signaling, genomic, and epigenomic data to generate mechanistic hypotheses and guide drug-discovery strategy.
• Develop and optimize fit-for-purpose cellular and molecular assays, including flow cytometry, PCR, ELISA, and primary-cell culture.
• Generate data to support therapeutic candidate selection and prioritization and to inform go/no-go decisions.
• Help shape the future discovery and innovation portfolio through identification and evaluation of new biological hypotheses and therapeutic opportunities.
• Partner closely with cross-functional R&D stakeholders to ensure seamless study execution, timely data delivery, and alignment across the pipeline.
• Establish and manage CRO partnerships, external scientific collaborations, and internal capabilities supporting therapeutic identification, assay development, and candidate selection.
• Contribute to regulatory filings, scientific publications, data interpretation, and other activities supporting program and portfolio objectives.
• Mentor and develop scientists while fostering a culture of scientific rigor, innovation, accountability, and collaboration.
• Maintain substantial hands-on laboratory involvement during the initial build-out of the function, with bench work expected to represent approximately 50% of the role initially, decreasing as the team grows.

What You Bring

• PhD with 8+ years of relevant experience in pharmacology, cell biology, hematology, molecular biology, or a related discipline; or MS with 10+ years of extensive relevant biopharmaceutical industry experience.
• Expert scientific and technical background in bone marrow biology and hematology, with demonstrated application to drug discovery, target identification, and/or development of novel therapeutic molecules.
• Extensive hands-on experience developing cell-based models of genetically defined human hematologic diseases.
• Strong expertise in kinase biology, phosphatase biology, and/or intracellular signaling pathways, with demonstrated experience using mechanistic studies to understand therapeutic response.
• Demonstrated experience with functional genomic and epigenomic approaches, including:
• Single-cell RNA sequencing (scRNA-seq)
• ATAC-seq
• o CUT&RUN and/or closely related chromatin-profiling approaches
• Ability to design rigorous genomic/epigenomic experiments, understand appropriate controls and technical considerations, critically interpret resulting datasets, and integrate findings with cellular and mechanistic biology.
• Deep hands-on expertise with core cellular biology techniques, including flow cytometry, PCR, ELISA, and cell culture.
• Demonstrated experience designing and implementing experimental strategies that generate mechanistic insight into hematologic disease biology and therapeutic correction.
• Proven scientific leadership, people leadership, and project management experience, including leading cross-functional, collaborative programs.
• Strong problem-solving, communication, organizational, and stakeholder-management skills.

Preferred Experience

• Direct hands-on execution and troubleshooting of multiple functional genomic/epigenomic techniques, particularly scRNA-seq, ATAC-seq, and CUT&RUN.
• Experience integrating multi-omic datasets with cellular phenotypes, signaling biology, and pharmacodynamic data.
• Experience advancing therapeutic programs through candidate selection and toward IND-enabling development.
• Experience contributing to regulatory filings.
• Experience managing GLP- and/or cGMP-compliant workflows.
• Experience establishing new laboratory capabilities and managing external CRO or academic collaborations.