Principal Research Scientist, Medicinal Chemistry

IDEAYA; South San Francisco (CA); Presencial; USD 177.000 - 218.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Medical/dental/vision coverage

401k

ESPP

Wellness programs

Descripción de la vacante

IDEAYA Biosciences is seeking a discovery medicinal chemist to join our South San Francisco team. You will lead synthetic chemistry efforts, propose target molecules, and work in cross‑functional teams to advance oncology programs onsite five days a week.

The role requires a Ph.D. in synthetic organic chemistry with 3–8 years of pharma medicinal chemistry experience, strong purification and characterization knowledge, and a track record of delivering complex molecules at pace.

Formación

• Ph.D. in synthetic organic chemistry with pharma medicinal chemistry experience.
• Strong knowledge of medicinal chemistry concepts and purification/characterization techniques.
• Ability to design practical, scalable chemistry and troubleshoot problems.

Responsabilidades

• Apply modern synthetic techniques to advance oncology programs and deliver high‑quality molecules.
• Design reaction sequences to avoid liabilities and reduce difficult purifications.
• Troubleshoot transformations and gather reaction information quickly.
• Plan and multitask to maintain high productivity in lab and team settings.
• Deliver molecules from 10 mg to >25 g and manage external resources.
• Communicate results and strategy clearly to inform cross‑functional teams.
• Use structure‑based design and computational tools to improve affinity and selectivity.
• Contribute to new directions to achieve program goals.

Conocimientos

Medicinal chemistry

Structure-based design

SAR‑driven design

Multi-parameter optimization

ADME principles

Oral and written communication

Educación

Ph.D. in synthetic organic chemistry

Herramientas

Computational tools

Descripción del empleo

Non-Solicitation Policy and Notice to Agencies and Recruiters: IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships. Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to [e-mail]. We ask that you only email your interest once.

About IDEAYA Biosciences

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class, targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody‑drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use teamwork to move science forward.

For more information, please see www.ideayabio.com.

Location

South San Francisco

Position Summary

We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team as a discovery medicinal chemist. The successful candidate will impact programs by being highly productive in lab and by rationally proposing target molecules that overcome liabilities to deliver clinical candidates molecules. You will be a part of dynamic, cross-functional teams that successfully deliver drug discovery pipeline goals. The responsibilities will include, but not be limited to, those listed below. This position is based in our South San Francisco headquarter offices and required to be onsite five days per week per our company policy.

Reporting to

Vice President, Medicinal Chemistry

Job Description

What you’ll do

• Apply modern synthetic techniques to prepare complex chemical targets to advance cutting‑edge oncology programs and deliver high‑quality molecules at a very productive rate
• Design high‑confidence reaction sequences that avoid known liabilities and reduce difficult purifications
• Rapidly gather reaction information and troubleshoot problematic transformations
• Plan ahead and multitask in and out of the lab to maintain high productivity
• Deliver molecules on scales from 10 mg to > 25 g
• Help manage external synthetic chemistry resources to high productivity
• Follow SAR data and leverage medicinal chemistry knowledge to propose targets that address critical issues within a chemical series
• Champion design and synthesis efforts into new directions as needed to achieve goals
• Clearly and concisely communicate results and strategy to inform and influence others
• Use structure‑based design skills and modern computational tools to design targets with improved affinity and selectivity profiles

Requirements

• Ph.D. in synthetic organic chemistry with 3-8 years of pharmaceutical industry medicinal chemistry experience
• Excellent scientific expertise in synthetic organic chemistry, including asymmetric reactions and modern cross‑coupling techniques, strong knowledge of modern chemistry literature and in‑depth knowledge of a wide range of purification and spectroscopic characterization techniques
• Demonstrated ability to maintain high productivity in the lab and synthesize complicated chemical structures at the pace required to impact medicinal chemistry programs while maintaining high safety standards
• Ability to develop new chemistry that is both practical and scalable
• Ability to regularly troubleshoot synthetic problems and provide practical and creative solutions
• Ability to keep good scientific records
• Ability to identify the most critical issues with the lead chemical matter for a project, associate those issues with chemical functionality or physicochemical properties within the series, and strategically focus most target design efforts toward fixing these issues
• Ability to multi‑task and set priorities in a fast‑paced and dynamic environment while demonstrating a positive attitude and superior work ethic
• Ability to work well in diverse, multi‑disciplinary teams
• Demonstrate excellent oral and written communication skills
• Strong knowledge of medicinal chemistry concepts, including structure‑based target design, SAR‑driven target design, multi‑parameter optimization, physicochemical properties of drugs, and ADME and pharmacological principles applied to drug discovery
• Ability to use modern computational tools to better understand trends in biological data found within a series of drug‑like molecules and to understand the underlying principles governing ligand binding
• Desire to continually learn drug discovery concepts and structure‑based design concepts and to stay current with the field while mentoring others

Total Rewards

The expected salary range for the role of Principal Research Scientist, Medicinal Chemistry is $177,000 - $218,000.

• Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay‑for‑performance philosophy where employees are eligible to be considered for merit‑based salary increases, company discretionary short‑term incentive plan participation, and company discretionary stock option awards (based on board approval).
• Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs.

Equal Employment Opportunity

The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. IDEAYA is an equal opportunity employer.

In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets. We are committed to providing reasonable accommodations to qualified individuals with disabilities. If you need assistance or an accommodation due to a disability, please get in touch with us at [e-mail].

Work Arrangements

At IDEAYA we believe in the importance of on‑site presence by all team members as an essential ingredient to effective collaboration. Our hybrid approach to work at IDEAYA includes all staff being on‑site four days per week in the office, and one day per week working from home.

IDEAYA Company Values

• Passionate
• Commitment
• Fearless Innovation
• Courageous Integrity
• Respectful Teamwork
• Objective Decision‑Making
• Empowered Accountability

For more information, please see www.ideayabio.com

California Job Applicant Privacy Notice