Principal Research Scientist I

AbbVie Inc.; Chicago (IL); On-site; USD 180,000 - 240,000; Full time

Job summary

AbbVie Inc. seeks a Principal Research Scientist to lead in vivo cardiovascular safety pharmacology across rodent, canine, and nonhuman‑primate models. You will design, execute, interpret, and report studies and ensure GLP compliance and regulatory readiness while guiding a matrixed team.

You will mentor scientists, communicate strategy and risk to senior leadership, and advance cardiovascular safety capabilities, workflows, and technologies in a collaborative, cross‑functional environment.

Qualifications

• PhD in physiology, pharmacology, toxicology or related field.
• 10+ years in cardiovascular biology, safety pharmacology, or related discipline.
• Experience with rodent and large-animal models (canine and NHP).
• Experience authoring and implementing SOPs; GLP knowledge.
• Experience leading in a matrixed environment; strong communication.

Responsibilities

• Lead design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety studies across rodent, canine, and NHP models.
• Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG, EPHYS, echocardiography, vascular reactivity, thrombosis and disease models.
• Develop/validate fit-for-purpose cardiovascular assays and SOPs; ensure regulatory readiness.
• Mentor scientists, communicate study strategy/results to senior leadership and regulatory teams; advance capabilities.
• Manage team members in a matrixed environment to plan, coordinate, and prioritize studies.

Skills

Scientific communication

Leadership in matrixed environment

Critical thinking

Troubleshooting complex studies

Time management

Education

PhD in physiology/pharmacology/toxicology/related field

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

Overview:

The Translational Safety Pharmacology department provides rigorous in vitro and in vivo safety assessments and fit-for-purpose assay development to enable informed discovery and development decisions. Cardiovascular safety pharmacology is central to advancing safe, high-quality medicines.

The Principal Research Scientist will serve as the in vivo cardiovascular safety pharmacology subject-matter leader, providing scientific and strategic leadership across rodent, canine, and nonhuman-primate models. This role leads the design, execution, interpretation, and reporting of cardiovascular safety studies; advances GLP and regulatory readiness; and partners across a matrixed organization to deliver reproducible, decision-ready data.

Responsibilities:

• Lead the design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety pharmacology studies across rodent, canine, and nonhuman-primate models.
• Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG and electrophysiology, pressure-volume loops, echocardiography, vascular reactivity, thrombosis, and relevant disease models.
• Develop, optimize, validate, and implement fit-for-purpose cardiovascular assays and models; author and implement SOPs that support quality, consistency, and regulatory readiness.
• Champion data quality, reproducibility, and scientifically sound interpretation; mentor scientists; communicate study strategy, results, and risk assessments to senior leadership, cross-functional stakeholders, and regulatory-facing teams; and advance cardiovascular safety pharmacology capabilities, workflows, and technologies.
• Manage (directly and indirectly) team members in a matrixed environment to help plan, coordinate, and prioritize studies.

Qualifications

• PhD in physiology, pharmacology, toxicology, or a related field, with 10+ years of relevant experience in cardiovascular biology, safety pharmacology, or a closely related discipline.
• Demonstrated cardiovascular biology and safety pharmacology expertise, including the ability to design, execute, interpret, and report in vivo cardiovascular studies.
• Experience with rodent and large-animal studies, including canine and nonhuman-primate models.
• Experience authoring and implementing SOPs, with working knowledge of GLP, quality systems, and regulatory-ready documentation.
• Strong written and verbal scientific communication skills; demonstrated ability to lead in a matrixed environment, apply critical thinking, troubleshoot complex study issues, and manage multiple priorities effectively.
• At least one year of previous people management experience

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employer remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

https://www.abbvie.com/join-us/reasonable-accommodations.html