Principal Quantitative Pharmacologist

Regeneron Pharmaceuticals; Village of Tarrytown (NY); On-site; USD 151,000 - 246,000; Full time

Benefits offered by this job

Annual bonuses

Equity awards

Pension/retirement benefits

401(k) company match

Health and wellness programs

Fitness centers

Insurance benefits

Paid time off

Family support benefits

Job summary

Regeneron Pharmaceuticals in Tarrytown, NY, is seeking a Principal Quantitative Pharmacologist in Pharmacometrics (PMx) to influence program development with advanced PMx analyses. The role emphasizes prospective PMx contributions to regulatory documentation and strategic program direction.

The position is onsite four days per week with opportunities to influence multiple trials and regulatory interactions, working within a collaborative PMx team.

Qualifications

• PhD or MS with industry experience in PMx or related pharmacometrics.
• Advanced pharmacokinetics and pharmacology principles expected.
• Familiarity with exposure–response and translational modelling is a plus.

Responsibilities

• Designs and conducts quantitative PMx analyses aligned with program strategy.
• Keeps PMx management informed of significant results.
• Communicates PMx results clearly to development teams.

Skills

Pharmacokinetics

Pharmacology basics

Non‑compartmental analysis

Exposure–Response

Translational modelling

Nonlinear mixed effects

Bayesian methods

Survival analysis

Education

PhD in relevant field

MS with industry experience

Job description

Build Our Future Together As a Principal Quantitative Pharmacologist in Pharmacometrics (PMx), this individual is encouraged to provide contributions to PMx results in support of programs. Is further able to prospectively provide PMx contributions in support of longer-term development strategies implemented over the course of multiple experiments, studies, and/or clinical trials.

When & where: Work Location: Tarrytown, NY Work model/flexibility: 4 days per week onsite

Discover your role

• Prospectively designs and conducts quantitative or other PMx analyses of a sophisticated nature or otherwise appropriate that is consistent with and encouraging of the program development strategy for one or more program.
• Keeps PMx management advised of significant PMx results.
• As a PMx Program Representative on program teams, efficiently communicate sophisticated PMx results in colloquial terms that are understandable across the development teams.
• Implements PMx management strategic or otherwise impactful changes to the program strategy, direction, and/or regulatory interactions.
• As a PMx Program Representative, with limited mentorship from PMx management is responsible for, authoring PMx contributions to regulatory documentation, such as IB’s, as well as briefing document for; pre-IND, EOP2, and other global Health Authority (HA) meetings.
• Is responsible for the preparation and timely delivery of accurate and well‑articulated study reports was well as regulatory submission documents as appropriate.
• Contributes accurate tables and figures for inclusion in slides for senior management presentations.
• Is able to independently draft and review documentation for accuracy, clarity and messaging to ensure documents are appropriate for further PMx management review.
• Performs additional analyses as required to support regulatory interactions.
• Share scientific ideas and contribute to the mentoring of PMx staff.
• With some supervision is able to competently represents PMx at pre‑IND, Type C, pre‑BLA, and other HA meetings.

This role requires

PhD with 5+ years or an MS degree with relevant industry experience. We expect this experience to include advanced pharmacokinetics, advanced pharmacological principles, non‑compartmental analysis methods. Familiarity with other methodologies such as exposure‑Response analysis methods, translational modelling/pharmacology, nonlinear Mixed Effects modelling, logistic regression, survival analysis, Bayesian approaches, disease modelling/QSP is also advantageous.

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.

Benefits

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

Please be advised that at Regeneron, we believe we do our best work when we are together. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location. As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. For jobs in Canada: this posting is for an existing position. Salary Range (annually) $150,500.00 - $245,500.00 Regeneron is a leading biotechnology company that invents life‑transforming medicines for people with serious diseases. Founded and led for over 30 years by physician‑scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA‑approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.