Principal Materials Engineer (Combination Devices)

MED Medtronic Inc; Shoreview (MN); On-site; USD 135,000 - 203,000; Full time

Benefits offered by this job

Health, Dental and vision insurance

Health Savings Account

Healthcare Flexible Spending Account

Life insurance

Long-term disability leave

Dependent daycare spending account

Tuition assistance/reimbursement

Simple Steps (well-being program)

Job summary

Medtronic's Electrophysiology Therapies group seeks a Principal Materials Engineer in the Cardiac Rhythm Management unit to advance materials selection, processing, and analysis for device-drug combinations, with emphasis on polymers, pharmacokinetics, and drug elution to inform product strategy and risk burndown.

The role supports regulatory compliance, data-driven decisions, and cross-functional collaboration, while working on-site four days per week and travelling less than 10% as needed.

Qualifications

• 7+ years of relevant experience with a bachelor’s degree or 3+ years with an advanced degree in chemistry, material science, chemical engineering, polymer science, or related field.
• For Baccalaureate degrees earned outside the United States, a degree that satisfies 8 C.F.R. § 214.2(h)(4)(iii)(A) is required.

Responsibilities

• Device-drug combination product support, development, and regulations
• Device-drug combination product characterization test methodologies
• Familiar with pharmaceutical test method validation, procedures and analytical test requirements
• Familiar with regulatory requirements around bioavailability and bioequivalence
• Utilize ICH, USP/EP, and 21CFR Parts 211/212 and 820
• Apply basic pharmacodynamics and pharmacokinetics principles (AUC, tmax, Cmax, t1/2)
• Coordinate and conduct laboratory work and data analysis to drive data-driven technical decisions
• Utilize formulation development for combination products
• Design benchtop testing and preclinical studies; understand GLP preclinical study requirements
• Support postmarket design changes, manufacturing support, CAPA, and troubleshooting
• Integrate product development and characterization testing into quality system and design controls

Education

Bachelor’s or advanced degree in chemistry, material science, chemical engineering, polymer science, or related field

Tools

Minitab

JMP

Job description

We anticipate the application window for this opening will close on - 31 Aug 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact.

A Day in the Life

The Electrophysiology Therapies (EPT) group is looking for their next Principal Materials Engineer within the Cardiac Rhythm Management (CRM) operating unit. EPT offers devices and therapies to treat abnormal heart rhythms, as well as cardiac diagnostic and monitoring solutions. This role will serve as an expert in combination devices by participating in technical activities for materials selection, processing, analysis, biostability, and process-property-performance relationships for medical devices. Additionally, this role will serve as a combination specialist with an emphasis on polymers and pharmacological applications, pharmacokinetics, and drug elution, informing current product strategy, product roadmap, and risk burndown. At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We are working on-site 4 days per week as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary. This role will require less than 10% of travel to enhance collaboration and ensure successful completion of projects.

• Device-drug combination product support, development, and regulations
• Device-drug combination product characterization test methodologies
• Be familiar with pharmaceutical test method validation, procedures and associated analytical test requirements
• Be familiar with regulatory requirements around bioavailability and bioequivalence
• Utilize ICH, USP/EP, and 21CFR Part 211/212 and Part 820
• Utilize basic pharmacodynamics and pharmacokinetics principles (AUC, tmax, Cmax, t1/2)
• Coordinate and conduct laboratory work and data analysis to drive data-driven technical decisions
• Utilize formulation development for combination products
• Design benchtop testing and preclinical studies; understand requirements for a GLP preclinical study
• Support postmarket design changes, manufacturing support, operational troubleshooting, and CAPA support
• Integrate product development and characterization testing into quality system and design controls; Be familiar with Design Verification and Design Validation requirements

Nice to Haves

• Expertise in materials with the ability to identify and develop testing methods, correlate material properties with product performance, and predict various failure modes
• cGMP experience
• Experience supporting product scaleup and launch
• Knowledge of external standards, e.g., ICH, ASTM and ISO, and their use, limitations, and applications
• Demonstrated ability to apply skills and knowledge of technical/operational theories and principles to resolve real-world biomaterials challenges
• Knowledge of statistical methods and Design of Experiments (DoE) using Minitab, JMP, or other statistical software

Must Have

7+ years of relevant experience with a bachelor’s degree OR 3+ years of relevant experience with an advanced degree in chemistry, material science, chemical engineering, polymer science, or related field. For Baccalaureate degrees earned outside of the United States, a degree that satisfies the requirements of 8 C.F.R. § 214.2(h)(4)(iii)(A) is required.

Physical Job Requirements

The above statements are intended to describe the general nature and level of work being performed by employees assigned to this position, but they are not an exhaustive list of all the required responsibilities and skills of this position. The physical demands described within the Responsibilities section of this job description are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. For Office Roles: While performing the duties of this job, the employee is regularly required to be independently mobile. The employee is also required to interact with a computer, and communicate with peers and co-workers. Contact your manager or local HR to understand the Work Conditions and Physical requirements that may be specific to each role.

U.S. Work Authorization & Sponsorship

At Medtronic, we are committed to fostering an environment where employees can thrive and make a meaningful impact. In alignment with our enterprise-wide workforce planning approach, U.S. work authorization sponsorship (H-1B, TN, J, etc.) is offered exclusively for Principal-level roles and above, where specialized expertise aligns with long-term business needs. Roles below the Principal level require candidates to possess unrestricted U.S. work authorization at the time of hire and for the duration of employment.

Benefits & Compensation

Medtronic offers a competitive Salary and flexible Benefits Package A commitment to our employees lives at the core of our values. We recognize their contributions. They share in the success they help to create. Salary ranges for U.S (excl. PR) locations (USD):$135,200.00 - $202,800.00 This position is eligible for a short-term incentive called the Medtronic Incentive Plan (MIP). The base salary range is applicable across the United States, excluding Puerto Rico and specific locations in California. The offered rate complies with federal and local regulations and may vary based on factors such as experience, certification/education, market conditions, and location. Compensation and benefits information pertains solely to candidates hired within the United States (local market compensation and benefits will apply for others).

• Health, Dental and vision insurance
• Health Savings Account
• Healthcare Flexible Spending Account
• Life insurance
• Long-term disability leave
• Dependent daycare spending account
• Tuition assistance/reimbursement
• Simple Steps (global well-being program)

The following benefits and additional compensation are available to all regular employees: Incentive plans, 401(k) plan plus employer contribution and match, Short-term disability, Paid time off, Paid holidays, Employee Stock Purchase Plan, Employee Assistance Program, Non-qualified Retirement Plan Supplement (subject to IRS earning minimums), and Capital Accumulation Plan (available to Vice Presidents and above, or subject to IRS earning minimums).

Regular employees are those who are not temporary, such as interns. Temporary employees are eligible for paid sick time, as required under applicable state law, and the Employee Stock Purchase Plan. Please note some of the above benefits may not apply to workers in Puerto Rico. Further details are available at the link below: Medtronic benefits and compensation plans

Equal Employment Opportunity Statement

It is the policy of Medtronic to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Medtronic will provide reasonable accommodations for qualified individuals with disabilities.

It is the policy of Medtronic to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Medtronic will provide reasonable accommodations for qualified individuals with disabilities.

If you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. Medtronic will consider for employment qualified job applicants with arrest or conviction records in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.

We lead global healthcare technology and boldly attack the most challenging health problems facing humanity by searching out and finding solutions. Our Mission — to alleviate pain, restore health, and extend life — unites a global team of 95,000+ passionate people. We are engineers at heart— putting ambitious ideas to work to generate real solutions for real people. From the R&D lab, to the factory floor, to the conference room, every one of us experiments, creates, builds, improves and solves. We have the talent, diverse perspectives, and guts to engineer the extraordinary. We change lives. Each team member, each day, helps to improve and redefine how the world treats the most pressing health conditions, from heart disease to diabetes. Our industry leadership comes from the passion and ingenuity of our people. That’s who we are. Working alongside one another, we use science, medicine, and a profound understanding of the human body to build extraordinary technologies that can transform lives. We build extraordinary solutions as one team. With one Medtronic Mindset defining how we work. Speed and decisiveness run through our DNA. Diverse perspectives inspire our bold answers to any challenge that comes our way. And we deliver results the right way, breakthrough after patient breakthrough. This life-changing career is yours to engineer. By bringing your ambitious ideas, unique perspective and contributions, you will… Build a better future, amplifying your impact on the causes that matter to you and the world Grow a career reflective of your passion and abilities Connect to a dynamic and inclusive culture that welcomes the challenge of life-long learning These commitments set our team apart from the rest: Experiences that put people first. Respect for people is the hallmark of our humanity. It fuels our team to positively impact even a single life. And it means we put our people first at Medtronic as well, creating a culture of belonging and always pushing to get you the career-building resources you need. Life-transforming technologies. No matter your role, you contribute to technologies that transform lives. What we build empowers patients to live life on their terms. Better outcomes for our world. Here, it’s about more than the bottom line. Our Mission to improve human welfare drives us. We advance healthcare, society, and equity with every design, inside and outside our walls. Insight-driven care. Fresh viewpoints. Cutting-edge AI, data, and automation. You're shaping the future of healthcare technology and defining the next generation of breakthroughs in care It is the policy of Medtronic to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Medtronic will provide reasonable accommodations for qualified individuals with disabilities. For sales reps and other patient facing field employees, going into a healthcare setting is considered an essential function of the job and we expect our employees to comply with all credentialing requirements at the hospitals or clinics they support. This employer participates in the federal E-reverify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here.