Principal Investigator, MD

Civia Health, LLC.; Independence (MO); On-site; USD 150,000 - 230,000; Full time

Benefits offered by this job

Competitive compensation

Medical, dental, and vision insurance

Generous PTO and paid holidays

Flexible scheduling options

Professional development support

Mission-driven team values

Job summary

Civia Health, LLC. is seeking an experienced Principal Investigator to oversee Phase 2–4 clinical trials. You will ensure scientific integrity, patient safety, and regulatory compliance while guiding a collaborative, mission-driven team.

Ideal candidates will hold an MD or DO with an active license and have 3+ years of PI experience, plus strong knowledge of GCP and FDA regulations. The role includes potential travel for audits and site visits, with a focus on patient-centered care and ethical

Qualifications

• MD or DO with active, unrestricted license.
• 3+ years as Principal Investigator in clinical research (Phase 2–4 preferred).
• Board certification in internal medicine, endocrinology, or related field preferred.
• Strong knowledge of GCP, FDA regulations, and clinical operations.
• Excellent leadership, communication, and problem-solving skills.
• Passion for innovation, ethics, and patient-centered care.

Responsibilities

• Serve as the physician of record and lead clinical oversight for assigned trials.
• Review and approve study protocols, informed consent documents, and source documentation.
• Conduct physical exams, medical reviews, and oversee safety assessments for participants.
• Ensure compliance with all ICH-GCP, FDA, and IRB regulations.
• Provide guidance and mentorship to the clinical research team.
• Engage with sponsors, monitors, and regulatory bodies as needed.
• Occasional travel may be required for audits, site visits, or team meetings.

Skills

GCP knowledge

Leadership

Communication

Problem solving

Patient-centered care

Education

MD/DO

Board certification in internal medicine or endocrinology

Job description

Reports to: Medical Director

Join Us at Civia Health

At Civia Health, we’re reimagining how clinical trials are delivered—by putting patients first and empowering providers to lead innovation. We’re seeking an experienced and compassionate Principal Investigator (PI) to oversee Phase 2–4 clinical trials in a collaborative, mission-driven environment. You’ll play a vital role in ensuring scientific integrity, patient safety, and regulatory compliance while contributing to groundbreaking research.

At Civia Health, you’re not just taking a job: You’re joining a mission to transform the way clinical research is done. Our purpose is bold: to bring clinical trials front and center in your community, make them accessible to everyday people, and empower underrepresented communities to participate.

We’re reinventing how clinical studies are run, delivering valid, scalable evidence with a consumer-first mindset. Too often, trials are expensive, fragmented, and overlook the experience of the participant. At Civia, we’re changing that. Our leadership team are experienced industry leading, visionary professionals who know what’s broken — and how to fix it.

We treat participants like valued partners, not research subjects. That means supporting their agency, putting their needs, comfort, and enjoyment first — and rewarding them generously for their time and effort.

What It Means to Work at Civia

Every team member plays a crucial role in reshaping clinical research. You’ll help make studies more human-centered, inclusive, and efficient. We’re looking for people who are driven by purpose, inspired by innovation, and ready to roll up their sleeves to do meaningful work.

At Civia, your contributions aren’t just transactional, they’re transformational.

What You’ll Do

• Serve as the physician of record and lead clinical oversight for assigned trials.

• Review and approve study protocols, informed consent documents, and source documentation.

• Conduct physical exams, medical reviews, and oversee safety assessments for participants.

• Ensure compliance with all ICH-GCP, FDA, and IRB regulations.

• Provide guidance and mentorship to the clinical research team.

• Engage with sponsors, monitors, and regulatory bodies as needed.

• Occasional travel may be required for audits, site visits, or team meetings.

What You Bring

• Medical degree (MD or DO) with active and unrestricted license.

• 3+ years of experience as a Principal Investigator in clinical research (Phase 2–4 preferred).

• Board certification in internal medicine, endocrinology, or related field preferred.

• Strong working knowledge of GCP, FDA regulations, and clinical operations.

• Excellent leadership, communication, and problem-solving skills.

• Passion for innovation, ethics, and patient-centered care.

What We Offer

• Competitive compensation

• Medical, dental, and vision insurance

• Generous PTO and paid holidays

• Flexible scheduling options

• Professional development and continuing education support

• A mission-driven team that values respect, inclusion, and innovation

Ready to Make an Impact?

• Mission with Meaning: Be part of a purpose-led team committed to health equity and real-world impact.

• Startup Energy, Proven Expertise: Work fast, adapt quickly, and help build something new; guided by seasoned visionaryprofessionals who’ve seen what needs to change.

• People First Culture: We care deeply about our patients, participants, and each other. Collaboration, transparency, and bold, straight-talking are core to how we work.

• Invested in Your Growth: We don’t just hire for today; we’re building the leaders and changemakers of tomorrow.