Principal Investigator

EPM Scientific; Springfield (MO); On-site; USD 180,000 - 300,000; Full time

Benefits offered by this job

Relocation assistance

On-site work

Job summary

EPM Scientific seeks an experienced physician to serve as the lead and sole Principal Investigator for its Springfield, Missouri research operation. This role offers high autonomy to lead trials and provide medical oversight across the portfolio.

You will lead early-phase industry-sponsored studies, ensure ICH-GCP compliance, oversee safety and informed consent, and mentor clinical research staff while collaborating with sponsors, IRBs, and monitors.

Qualifications

• MD or DO required.
• Strong knowledge of ICH-GCP and clinical research regulations.
• Experience leading clinical trials and teams.
• Interest in endocrinology, diabetes, obesity or related fields is a plus.

Responsibilities

• Lead and oversee early-phase industry-sponsored trials as the sole Principal Investigator.
• Ensure studies are conducted in accordance with ICH-GCP guidelines and protocol requirements.
• Oversee participant safety, informed consent, and study conduct.
• Collaborate with sponsors, IRBs, monitors, and auditors.
• Provide leadership and mentorship to clinical research staff.
• Support overall study quality, regulatory compliance, and data integrity.

Skills

ICH-GCP knowledge

Clinical leadership

Regulatory compliance

Medical oversight

Education

MD or DO

Job description

Principal Investigator -Clinical Research

Relocation Assistance Available

Full-Time | On-Site

About the Opportunity

An established global clinical research organization is seeking an experienced physician to serve as the lead and sole Principal Investigator for its Springfield, Missouri research operation.

This is not a traditional study-level PI position. The physician will hold meaningful authority across the clinical research portfolio, leading their own trials while providing senior medical oversight, guiding research teams, and supporting additional PRN and contract investigators.

This is an opportunity to become the primary clinical leader within a sophisticated research environment and directly influence how trials are conducted.

Why Consider This Opportunity?

• Serve as the sole, senior Principal Investigator for the research operation
• Established clinical research program with decades of experience
• Broad exposure to Phase I-IV clinical trials
• Opportunity to mentor research staff and support other investigators
• High level of autonomy and physician leadership
• Collaboration with leading pharmaceutical and biotechnology sponsors
• Operate with meaningful autonomy within an established global organization

Key Responsibilities

• Serve as Principal Investigator for early-phase industry-sponsored clinical trials
• Ensure studies are conducted in accordance with ICH-GCP guidelines and protocol requirements
• Oversee participant safety, informed consent, and study conduct
• Review eligibility criteria and perform medical assessments
• Evaluate adverse events and ongoing participant safety
• Collaborate with sponsors, IRBs, monitors, and auditors
• Provide leadership and mentorship to clinical research staff
• Support overall study quality, regulatory compliance, and data integrity

Qualifications

• MD or DO
• Board Certified or Board Eligible (preferred but not required)
• Strong knowledge of ICH-GCP and clinical research regulations
• Experience in Endocrinology, Diabetes, Obesity, Metabolic Disease, Thyroid Disease, Internal Medicine, or related therapeutic areas preferred
• Strong interest in clinical research