Principal Engineer, AI Authoring

Vertex Pharmaceuticals; Boston (MA); On-site; USD 166,640 - 250,000; Full time

Benefits offered by this job

Hybrid work model

On-site option

Job summary

Vertex Pharmaceuticals seeks a Principal Engineer, AI Authoring in Boston, hybrid/onsite. Lead the architecture for AI-driven content generation, focusing on modular LLM integration, prompt engineering, and retrieval pipelines to support compliant regulatory documents. Drive RAG-based systems and scalable cloud workloads.

You will prototype AI features, ensure rigorous testing and validation, and collaborate with a cross-functional team to deliver high-quality, regulated outputs.

Qualifications

• Experience building AI-driven platforms with LLMs and RAG architectures.
• Expertise in prompt engineering and retrieval pipelines.
• Strong background in structured and unstructured data integration.
• Experience with automated testing/validation in regulated environments.

Responsibilities

• Design end-to-end architecture for AI-assisted document generation with modular LLM integration.
• Build and optimize Retrieval-Augmented Generation systems pulling from clinical/regulatory data sources.
• Engineer data connectors/transformations for feeding data into AI models.
• Develop automated testing/validation to meet compliance standards in Life Sciences.
• Prototype new AI features to assess viability before full-scale dev.

Skills

AI platform design

LLM integration

RAG architectures

Prompt engineering

Data workflows

Automated testing

Cloud optimization

Cross-functional collaboration

Education

Bachelor’s or Master’s in CS/AI/Data Science

Job description

## Principal Engineer, AI AuthoringApplylocations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-28761**Job Description****Position Summary**:We are seeking a highly skilled and visionary Principal Engineer, AI Authoring to join our AI Authoring Platform team. Reporting to the Director of AI Authoring Platform, you will lead the design, development, and optimization of Vertex’s AI-driven content generation engine. This role is pivotal in shaping the technical architecture of our platform, ensuring the performance, accuracy, and scalability of our LLM-powered authoring tools. You will tackle complex engineering challenges, including automated document workflows and Retrieval-Augmented Generation (RAG)-based architectures, to support the creation of high-quality, compliant, and efficient regulatory documents.**Key Duties and Responsibilities*** Design and maintain the end-to-end technical architecture for AI-assisted document generation, focusing on modular LLM integration, prompt engineering, and retrieval pipelines, while partnering closely with the AI Architect to ensure alignment with enterprise standards and scalability.* Build and optimize sophisticated Retrieval-Augmented Generation (RAG) systems that accurately pull from vast clinical and regulatory data sources to assist in document creation.* Engineer the data connectors and transformations required to feed structured and unstructured data into AI models for automated document population.* Develop and implement automated testing and validation frameworks to ensure AI-authored outputs meet the strict safety and compliance standards of the Life Sciences industry.* Rapidly prototype new AI authoring features, such as automated summarization or cross-document consistency checks, to determine technical viability before full-scale development.* Serve as the final escalation point for complex technical blockers, from debugging model hallucinations to optimizing cloud infrastructure for high-compute AI workloads.**Knowledge and Skills*** Proven experience in designing and implementing AI-driven platforms, particularly those leveraging LLMs and RAG architectures.* Expertise in prompt engineering, retrieval pipelines, and modular AI system design.* Strong background in engineering data workflows, including structured and unstructured data integration.* Experience with automated testing and validation frameworks, particularly in regulated industries.* Proficiency in cloud infrastructure optimization for AI workloads.* Exceptional problem-solving skills, with the ability to address complex technical challenges.* Strong collaboration and communication skills to work effectively with cross-functional teams* Familiarity with the Life Sciences industry and its compliance requirements (preferred).* Experience with automated document workflows and AI-based content generation (preferred).**Education and Experience*** 8+ years of experience in software engineering, with a focus on AI, machine learning, or technical platform development.* Proven track record of leading the design and implementation of AI-driven systems, including LLM-based platforms and RAG architectures.* Bachelor’s or Master’s degree in Computer Science, Artificial Intelligence, Data Science, or a related technical field.* Hands-on experience with cloud platforms (e.g., AWS, Azure, or GCP) and distributed computing systems.* Demonstrated expertise in building and deploying production-grade AI/ML systems in complex, data-intensive environments.* Experience working in regulated industries, such as Life Sciences, is a strong plus.**Why Join Us?**At Vertex, you will have the opportunity to work on cutting-edge technologies that make a real difference in people’s lives. We offer a collaborative and innovative work environment, competitive compensation, and opportunities for professional growth.If you are passionate about leveraging AI to revolutionize content generation and thrive in solving complex engineering challenges, we encourage you to apply and join our mission to transform lives through innovation.#LI-HYBRID**Pay Range:**$166,640 - $250,000**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**Hybrid-Eligible Or On-Site Eligible**Flex Eligibility Status:**In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.