Principal Electrical Engineering Architect

Seer Inc.; Redwood City (CA); On-site; USD 175,000 - 205,000; Full time

Benefits offered by this job

Stock options

Bonus eligible

Benefits

Job summary

Seer Inc. in Redwood City seeks an Electrical Engineering Architect to lead the electrical design of a next-generation mass spectrometer for proteomics workflows. You will architect HV DC and RF systems, ensure signal integrity, and drive low-noise electronics in high-vacuum environments.

Reporting to the Director of Systems Integration, you will collaborate across teams to deliver precise ion beam control and instrument performance in LCMS applications.

Qualifications

• Advanced degree in EE/related field required.
• 10+ years in academic or biotech labs with MS-focused experience.
• Experience architecting MS or similar instrumentation.
• Proven high-voltage DC and RF electronics designs.
• Strong signal integrity and low-noise analog expertise.
• Ability to work in a fast-paced, collaborative team.

Responsibilities

• Lead electrical system layout for a next-gen TOF MS.
• Specify 15 kV DC power supply architecture for ion optics.
• Develop robust 1-2 MHz RF systems for ion guides and traps.
• Implement grounding, shielding, and isolation strategies.
• Minimize noise, ripple, and thermal drift in ion beams.
• Oversee HV electronics integration in high-vacuum systems.

Skills

Mass spectrometry

High voltage electronics

RF electronics

Signal integrity

Low-noise analog design

Precision timing circuits

Team collaboration

Education

Master’s or Ph.D. in Electrical Engineering or related

Tools

High-voltage DC power supply

High-vacuum integration

Job description

At Seer, we are passionate about empowering our customers to expand scientific discoveries and achieve exceptional scientific outcomes. Our team is growing quickly as we develop innovative approaches to solve complex biological questions. And we believe the next frontier in biology is enabled through a clearer and more complete view of the proteome – something that Seer can uniquely deliver. As we build our team, we are looking for collaborative, driven, intellectually curious people who are committed to solving complex challenges. Our culture rewards accountability and cross‑functional teamwork, because we believe that this enables the kind of breakthrough thinking that will accelerate our mission.

The Role & The Team

This role will report to the Director of Systems Integration and join our team based in our Redwood Shores facility.

We are seeking a highly skilled Electrical Engineering Architect to lead the electrical design of a next‑generation mass spectrometer for life sciences applications. This role requires deep technical expertise in managing the complex electromagnetic environments inherent to charged particle beam instrumentation. You will be responsible for architecting systems that demand extreme precision, stability, and immunity to noise, ensuring optimal ion beam fidelity for advanced analytical workflows, including liquid chromatography‑mass spectrometry (LCMS).

Responsibilities & Goals

This special projects group is focused on using the latest product development and associated instrumentation for proteomics molecular profiling. Areas of specific responsibility and attention will include:

• Architect the comprehensive electrical system layout for a novel TOF mass spectrometer.
• Specify high‑voltage DC power supply architecture (up to 15 kV) for precision ion optics and flight tubes.
• Develop robust high‑voltage RF systems (≈1‑2 MHz, ≈4 kV amplitudes) for ion guides, funnels, quadrupoles, and traps. Ensure high stability and low temperature drift.
• Implement rigorous grounding, shielding, and isolation strategies to mitigate RF pickup on lenses and signal lines.
• Engineer component‑level solutions to minimize electronic noise, voltage ripple, and thermal drift that negatively impact ion beam trajectories, mass resolution, and mass accuracy.
• Oversee the integration of high‑voltage electronics within high‑vacuum systems and define system‑level cabling and interconnect strategies.

Background & Qualifications

The successful candidate will have deep hands‑on experience with mass spectrometry with expertise spanning sample preparations through data analysis. Candidates must bring a strong entrepreneurial orientation along with teamwork skills and commitment to competing with the highest level of integrity and engagement.

Requirements include:

• Master’s degree or Ph.D. in Electrical Engineering, Applied Physics, or a closely related discipline.
• Minimum 10+ years of experience in an academic or life‑sciences industry laboratory setting (biotech start‑up experience preferred).
• Demonstrated architectural design experience with mass spectrometers, electron microscopes, focused ion beam systems, particle accelerators or other similar technology.
• Proven track record of designs implementing high voltage DC and high amplitude RF electronics.
• Extensive practical knowledge of signal integrity, ultra‑low noise analog circuit design, and precision timing circuits.
• Deep understanding of the physical challenges associated with guiding low‑energy ion beams without introducing phase‑space distortion.
• Strong written and oral communication skills, with demonstrated experience in cross‑functional and timely communication.
• Strong and collaborative work ethic; must be a self‑starter and persistent in achieving objectives to support Seer’s scientific and business goals.
• Must work well in a small team setting, with the ability to work independently and collaboratively, while meeting scheduled deadlines in a fast‑paced environment.

Physical Requirements

• Prolonged periods of sitting at a desk and working on a computer.
• Prolonged periods of standing.
• Frequently lift, carry, push, pull or otherwise move objects with minimal force. Repetitive movements.
• Ability to wear PPE for prolonged periods.
• Must be able to lift up to 15 pounds at times.

Compensation

At Seer, base pay is one part of our total compensation package and is determined within a range. This provides the opportunity to progress as you grow and develop within a role. The base pay range for this role is between $175,000 and $205,000, and will depend on the candidate’s education, skills, qualifications, experience, and location. This position is also eligible for bonus, benefits, and participation in Company’s stock option plan.

Equal Opportunity

Seer is an equal opportunity employer that values diversity and inclusion. All applicants will be considered for employment without attention to race, color, national origin, religion, gender, gender identity, sexual orientation, age, marital status, veteran status, or disability status. If you are interested in applying for employment and need special assistance or an accommodation to apply for a posted position, contact our Human Resources department at [e-mail]. See also Seer’s EEO Policy.

Seer is also an affirmative action employer, has an affirmative action plan (AAP), and seeks to abide by all applicable state laws and regulations for applicant notifications. For questions about or to view Seer’s AAP, including with respect to veterans and individuals with disabilities, please reach out to [e-mail] to schedule a meeting. For additional information on applicant notifications, please visit the links below:

• Family and Medical Leave Act
• Pay Transparency Nondiscrimination Provision
• E-Verify Participation Notice
• Anti-Discrimination Notice/Right to Work