Principal Business Manager, Early Clinical Development (ECD)

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 136,000 - 253,000; Full time

Benefits offered by this job

Discretionary annual bonus

Onsite campus in South San Francisco

Job summary

Genentech, a Roche subsidiary based in South San Francisco, seeks an experienced ECD Business Manager to guide long-term strategy, resource planning, and enterprise-wide initiatives. The role partners with the Leadership Team and senior leaders, requiring on-site presence 3–4 days per week, and oversees budgets, forecasts, and program execution.

The position emphasizes strategic leadership, stakeholder engagement, and effective change management to balance innovation with enterprise guardrails.

Qualifications

• 5–10 years in business management, cross-functional initiatives, or operations programs (clinical development experience preferred).
• Bachelor’s degree required; certifications in project management or process improvement preferred (PMP, Six Sigma, Agile, Change Management).

Responsibilities

• Acts as a strategic advisor to executive leadership, guiding priorities and enterprise strategy.
• Leads annual planning, resource forecasting, budget oversight, and program execution across the department.
• Facilitates leadership meetings with clear agendas, documentation, and follow-up on actions.

Skills

Strategic planning

Project management

Cross-functional collaboration

Change leadership

Business process improvement

Communication

Education

Bachelor’s degree

Job description

We advance science so that we all have more time with the people we love. The Early Clinical Development (ECD) Business Manager acts as a key strategic advisor to the assigned Leadership Team and Senior Leaders within gRED ECD. Reporting directly to the ECD Chief of Staff, this role leads short- and long-term business planning, strategy formulation, resource allocation, budget oversight, and execution across the department. This position requires SSF on-campus presence between 3 to 4 times a week based on business demands.

Cross-Functional Collaboration: Fosters team alignment and builds networks across functions, enterprise teams, and external partners to achieve key milestones.

Talent & Team Engagement: Drives talent development, engagement programs, departmental workshops, and recognition initiatives to foster professional growth.

Strategic Leadership Partnership: Serves as a thought partner to executive leadership, advising on priorities, providing constructive challenge, and driving short- and long-term enterprise strategy.

Meeting Facilitation & Action Tracking: Structures leadership meetings with clear agendas, concise documentation, and rigorous follow‑up on action items.

Business & Financial Planning: Oversees annual planning, resource forecasting, budget allocation, and goal setting.

Operational Strategy & Innovation: Balances innovation with guardrails, recommending operational strategies to address evolving enterprise needs.

Complex Problem Solving: Resolves complex business challenges by mobilizing stakeholders and aligning functional goals with broader organizational priorities.

Working Hours: Ability to work over 8 hours/day or 40 hours/week, including early morning or late-night calls, to meet business demands.

Rapid Responsiveness: Capacity to respond promptly to emails and phone calls as business needs arise.

Physical Capability: Ability sitting or standing for extended periods during back-to-back meetings.

Onsite Mobility: Ability to carry up to 10 lbs of materials and travel between campus buildings for meetings and offsites.

Travel: Ability to travel domestically and internationally as needed.

Who You Are:

Education & Certifications: Bachelor’s degree required; project management or process improvement certifications (PMP, Six Sigma, Agile, Change Management) preferred.

Experience: 5–10 years in business management, cross‑functional initiatives, or operations programs (clinical development experience preferred).

Core Competencies: Expertise in strategic planning, project management, business process improvement, and team facilitation.

Problem Solving & Innovation: Proactive problem solver skilled at challenging standard processes, proposing creative solutions, and adapting to fast‑changing demands.

Communication & Relationships: Strong written, oral, and presentation skills with a proven ability to build transparent, productive cross‑functional relationships.

Change Leadership: Demonstrated ability to develop and execute change management and communication strategies across the enterprise.

Onsite presence on our South San Francisco campus is expected for at least 3 days a week.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $136,100 - $252,700. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

Benefits #ECD Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life‑threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.