Principal Biologics Production Scientist (Remote)

Disc Medicine; Watertown (MA); Hybrid; USD 166,000 - 203,000; Full time

Job summary

Disc Medicine, a clinical-stage biopharmaceutical company in Watertown, MA, seeks a detailed-oriented Principal Scientist/Associate Director to lead discovery and design of biologics across stages. You will steer protein production, develop assays, and guide developability assessments in a fast-paced Innovation portfolio.

You will communicate updates to cross-functional teams and advance pipeline programs, with a focus on antibodies and multi-specifics, while contributing to a collaborative,

Qualifications

• Ph.D. required in Biochemistry, Structural Biology, Protein Engineering, or related field.
• 10–12 years of research experience with 5+ years in biotech/pharma.

Responsibilities

• Provide scientific leadership across multiple biologics discovery programs.
• Lead protein engineering strategies for antibodies and multi-specifics.
• Oversee protein production and detailed characterization for discovery projects.
• Drive early-stage developability assessment workflows for biologics.
• Support mechanism of action studies through assay development.
• Assist lead molecule selection for pipeline advancement.
• Critically evaluate literature and design innovative experimental plans.
• Communicate progress and findings in cross-functional meetings.
• Foster collaboration and scientific excellence within the team.

Skills

Biochemistry

Structural biology

Protein engineering

Communication

Education

Ph.D. in Biochemistry/Structural Biology/Protein Engineering

Tools

Protein design software

Computational biology tools

Job description

Disc Medicine, a clinical-stage biopharmaceutical company in Watertown, MA, seeks a detailed-oriented Principal Scientist/Associate Director to lead discovery and design of biologics across stages. You will steer protein production, develop assays, and guide developability assessments in a fast-paced Innovation portfolio.

You will communicate updates to cross-functional teams and advance pipeline programs, with a focus on antibodies and multi-specifics, while contributing to a collaborative,