Principal Analytical Scientist (Automation)

Regeneron Pharmaceuticals, Inc (USA); United States; On-site; USD 92,200 - 150,600; Full time

Job summary

Regeneron Pharmaceuticals, Inc (USA) is seeking a Principal Analytical Scientist to join the Quality Control team in Rensselaer, NY. This role involves leading the design and optimization of automated assay workflows while mentoring junior scientists and ensuring high standards in analytical testing.

The ideal candidate will have extensive experience in analytical development and laboratory automation, particularly in mass spectrometry and chromatography. The salary range is competitive, reflecting the complexity and importance of the role within the organization.

Qualifications

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management.
• Hands-on experience programming automated liquid handling systems and scripting in Python, R, or VBA.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Strong troubleshooting skills across analytical methods and automated instrumentation.
• Ability to work independently and drive projects to completion.

Responsibilities

• Lead the design and optimization of automated assay workflows.
• Mentor and develop junior scientists.
• Independently design studies to evaluate automation technologies.
• Prepare scientific reports and communicate findings to teams.

Skills

Analytical development

Laboratory automation

Quality Control method lifecycle management

Mass spectrometry

Chromatography

Troubleshooting

Python scripting

Communication skills

Mentoring

Education

Ph.D. in Chemistry, Biochemistry, Biology or related field

Tools

Hamilton/Venus liquid handling systems

Andrew+/OneLab

Cellario

Job description

Overview

We are seeking a Principal Analytical Scientist to join our Quality Control team in Rensselaer, NY, supporting the IOPS organization on-site. In this role you will shape the future of QC analytical testing by designing, developing, and scaling automated assay workflows across advanced laboratory platforms, while mentoring scientists and fostering a culture of technical growth and innovation.

Responsibilities

• Lead the design, implementation, and optimization of automated assay workflows across modern laboratory platforms, applying deep expertise in mass spectrometry, chromatography, bioassay, electrophoresis, and ELISA.
• Mentor and develop junior and mid‑level scientists, building team capability in analytical science and laboratory automation.
• Set priorities, coordinate work, and track progress on analytical and automation initiatives against key milestones.
• Independently design and execute studies to evaluate emerging automation technologies and troubleshoot existing systems with limited supervision.
• Lead complex investigations into automated method performance, supporting verification activities and driving continuous improvement.
• Transfer automated workflows to QC and partner functions by developing training materials, transfer plans, and acceptance criteria.
• Engage cross‑functional collaborators and equipment vendors to evaluate new technologies and assess their fit for QC applications.
• Prepare clear scientific reports, automation procedures, and SOPs; communicate findings, risks, and mitigation strategies to management and cross‑functional teams.

Qualifications

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management (or equivalent combination of education and experience).
• Hands‑on experience programming and optimizing automated liquid handling systems (eg, Hamilton/Venus, Andrew+/OneLab, or Cellario) and scripting in Python, R, or VBA.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Strong troubleshooting skills across both analytical methods and automated instrumentation to resolve complex technical challenges.
• Ability to work independently, design scientifically sound studies from broad objectives, and drive projects to completion.
• Excellent communication skills and ability to convey complex automation concepts to diverse audiences.
• Experience mentoring or training scientists is desirable.
• A Ph.D. in Chemistry, Biochemistry, Biology, or a related field is preferred.
• Experience working in cGMP or cGLP regulated environment is preferred.
• Familiarity with Cellario, Venus (Hamilton), or OneLab (Andrew+) automation platforms is preferred.
• Experience developing and executing technology transfer plans across QC or partner functions is preferred.

Shift Requirements

• Standard 1st shift, Monday–Friday, 8:00 a.m.–4:30 p.m.

Physical Requirements

• Ability to work in a laboratory environment, including standing for extended periods and handling laboratory equipment.
• Work in a GMP analytical laboratory; appropriate gowning and PPE required.

Salary Range

Annually: $92,200.00 – $150,600.00.

Equal Employment Opportunity

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender identity or expression, or other characteristics protected by law.