Principal Analytical Scientist (Automation)

Regeneron; Town of East Greenbush (NY); On-site; USD 92,200 - 150,600; Full time

Benefits offered by this job

Annual bonuses

401(k) company match

Health and wellness programs

Paid time off

Job summary

Regeneron in Rensselaer, NY, is seeking a Principal Analytical Scientist to shape the future of QC analytical testing. You will design, develop, and scale automated assay workflows while mentoring scientists in a fast-growing, science-driven organization.

The ideal candidate will have 8+ years of experience in analytical development, proficiency in automated liquid handling and programming, and be able to work independently to drive projects to completion.

This role requires strong communication skills and the ability to thrive in a collaborative environment.

Qualifications

• 8+ years of industry experience in analytical development and QC method lifecycle management.
• Hands-on expertise in automated liquid handling platforms like Hamilton or Andrew.
• Proficiency in scripting languages for data analysis and workflow automation.

Responsibilities

• Lead the design and optimization of automated assay workflows.
• Mentor junior scientists and enhance team capability.
• Design and execute studies for emerging automation technologies.

Skills

Automated liquid handling systems programming

Troubleshooting analytical methods

Independent decision-making

Communication of complex automation concepts

Mentorship and training

Education

PhD in Chemistry, Biochemistry, Biology, or related field

Tools

Mass spectrometry

Chromatography

Electrophoresis

ELISA

Python

R

VBA

Job description

At Regeneron, we use science and innovation to develop life‑changing medicines for people with serious diseases. We are seeking a Principal Analytical Scientist to join our Quality Control team in Rensselaer, NY, supporting our IOPS organization on‑site. In this role, you will shape the future of QC analytical testing by designing, developing, and scaling automated assay workflows across advanced laboratory platforms, while mentoring scientists and fostering a culture of technical growth and innovation. This position offers the opportunity to contribute to a fast‑growing, science‑driven organization making a meaningful difference to patients worldwide.

When & Where

Location: Rensselaer, NY (Tempel Lane)

Work Model: On‑site

Travel: Minimal

Discover Your Role

Responsibilities

• Lead the design, implementation, and optimization of automated assay workflows across modern laboratory platforms, applying deep expertise in mass spectrometry, chromatography, bioassay, electrophoresis, and ELISA.
• Mentor and develop junior and mid‑level scientists, building team capability in analytical science and laboratory automation.
• Set priorities, coordinate work, and track progress on analytical and automation initiatives against key milestones.
• Independently design and execute studies to evaluate emerging automation technologies and troubleshoot existing systems with limited supervision.
• Lead complex investigations into automated method performance, supporting verification activities and driving continuous improvement.
• Transfer automated workflows to QC and partner functions by developing training materials, transfer plans, and acceptance criteria.
• Engage cross‑functional collaborators and equipment vendors to evaluate new technologies and assess their fit for QC applications.
• Prepare clear scientific reports, automation procedures, and SOPs; communicate findings, risks, and mitigation strategies to management and cross‑functional teams.

This Role Might Be for You if You…

• Bring hands‑on experience programming and optimizing automated liquid handling systems (e.g., Hamilton/Venus, Andrew+/OneLab, or Cellario) and scripting in Python, R, or VBA.
• Apply strong troubleshooting skills across both analytical methods and automated instrumentation to resolve complex technical challenges.
• Make sound, independent decisions and proactively recommend experiments or solutions based on deep expertise in analytical science and automation.
• Lead by example in technical discussions, elevating the team’s capabilities in automation strategy, method development, and process optimization.
• Thrive in a collaborative, fast‑paced environment and can prioritize effectively across multiple responsibilities while adapting to evolving business needs.
• Communicate complex automation concepts clearly to diverse audiences—both in written reports and in cross‑functional settings.
• Proactively share knowledge and take pride in developing others through structured training and mentorship.
• Deliver on commitments safely, with high quality, and in compliance with regulatory expectations.

Shift Requirements

Standard 1st shift, Monday–Friday, 8:00 a–4:30 p.

Must‑Haves

• 8+ years of industry experience in analytical development, laboratory automation, and QC method lifecycle management (or equivalent combination of education and experience).
• Demonstrated hands‑on expertise in automated liquid handling platforms and associated software programming.
• Proficiency in scripting languages (Python, R, or VBA) for data analysis, workflow automation, or system integration.
• Deep knowledge of QC analytical techniques including mass spectrometry, chromatography, electrophoresis, bioassay, or ELISA.
• Proven ability to work independently, design scientifically sound studies from broad objectives, and drive projects to completion.
• Level will be determined based on qualifications at the time of offer.

Preferred / Nice to Haves

• PhD in Chemistry, Biochemistry, Biology, or a related field.
• Previous experience working in a cGMP or cGLP regulated environment.
• Familiarity with Cellario, Venus (Hamilton), or OneLab (Andrew+) automation platforms.
• Experience developing and executing technology transfer plans across QC or partner functions.

Physical Requirements

Ability to work in a laboratory environment, including standing for extended periods and handling laboratory equipment.

Gowning & Environment

This role operates in a GMP analytical laboratory. Appropriate gowning and PPE are required in designated areas.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Salary Range (annually)

$92,200.00 - $150,600.00