Precision Medicine Scientific Lead - Neuroscience

BioSpace; Shanghai (VA); On-site; USD 150,000 - 239,000; Full time

Job summary

AbbVie in China seeks a senior Precision Medicine Scientific Lead - Neuroscience to drive translational science and biomarker strategies for neuroscience programs. You will lead global translational activities, coordinate with Medical Affairs and Commercial, and manage biomarker development across early to late-stage programs within the China context.

We seek a scientist with a strong publication record in neuroimmunology or related fields, capable of directing external collaborations and

Qualifications

• PhD/MD/PharmD with 5+ years or MS with 10+ years in pharma or equivalent.
• Strong translational science background with neuroscience focus.
• Experience leading biomarker programs and translational medicine strategies.
• Excellent communication and cross-functional leadership in a matrix environment.

Responsibilities

• Lead translational and biomarker strategic plans for China-developed compounds.
• Manage one or more clinical programs from translational to lifecycle stages.
• Design and oversee biomarker data generation, analysis and reporting.
• Coordinate China-based activities with internal operations and CROs.
• Ensure budgets, timelines and regulatory considerations are integrated into strategy.
• Author and review translational medicine sections of clinical/regulatory documents.

Skills

Translational sciences

Neuroscience

Neuroimmunology

Biomarkers

Leadership

Scientific communication

Data management

Collaboration with external partners

Education

PhD/MD/PharmD

MS with 10+ years experience

Tools

External CRO management

Biomarker assays

Data visualization tools

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

As a China Precision Medicine Scientific Lead - Neuroscience, he/she will have the opportunity to work in a fast-paced and highly collaborative environment to lead the development and execution of Precision Medicine strategies for Neuroscience programs in early/late-stage clinical development. The successful candidate will work with a global Precision Medicine Team responsible for development and execution of translational research and clinical biomarker strategies (patient selection/predictive/pharmacodynamic/target engagement biomarkers, molecular and functional response endpoints, indication selection, and combination strategies) in alignment with the overall asset strategy. This role requires an exceptional translational scientist with outstanding communication and leadership skills to drive effective decisions with key cross-functional stakeholders and enable execution of the overall Precision Medicine strategy for the program.

In This Role You Will

• Lead the development, planning and implementation of translational and biomarker strategic plans for AbbVie-developed compounds solely developed in China. Collaborate and provide expertise and input to partner-developed compound programs in China. Ensure development, planning, and implementation of global development programs, led by US-based PMED asset leads, are appropriate for the Chinese regulatory and research environment in China.
• Manage responsibility for one or more clinical programs that may extend from early translational development activities to mature product life cycle strategies.
• Regardless of development model, support the design and manage the conduct, interpretation, and reporting of biomarker data/activities in China in line with the development, regulatory, and commercial strategies.
• Ability to lead or support asset-specific translational projects/teams in a matrix environment.
• Work with internal Operations group to coordinate China-based activities such as sample management, technical validation of assays both internally and at external CROs, review of SOWs, and data management.
• In collaboration with appropriate stakeholders ensure that China-specific clinical translational budgets, timelines, publication strategies, and regulatory compliance requirements are incorporated into program strategy.
• Author and review all translational medicine aspects of clinical and regulatory documents including development plans, study protocols, HGRAC application dossier, clinical study reports, and regulatory submissions.
• Lead scientific collaborations and therapeutic area key opinion leader interactions in collaboration with partners from Medical Affairs, Commercial, or other functions.
• Proactively consult primary scientific literature, keep current on state of art technologies and emerging concepts in immunology.

Qualifications

• PhD, PharmD and/or MD with 5+ years or MS with 10+ years of experience in the pharmaceutical industry or equivalent; substantial understanding of Translational Sciences and immunology Therapeutic Area required. Will hire at level according to experience.
• Strong scientific background in neuroscience or related field supported by publication record in these areas.
• Expertise in neuroimmunology, neurodegeneration, migraine/pain or psychiatry highly desirable.
• Knowledge of clinical trial methodology, regulatory requirements governing clinical trials, protocol design, and/or experience in development strategy preferred.
• Demonstrated leadership in translational sciences (employing pharmacodynamic, predictive and exploratory biomarkers). Experience with some of the relevant neuroscience approaches such as fluid based biomarkers, imaging techniques, functional brain measures (e.g., EEG) and/or digital approaches is highly desirable. Experience successfully establishing and managing external collaborations.
• Ability to manage clinical translational programs and teams with minimal supervision.
• Organization, detail oriented, and effective time management with an ability to adapt to changing priorities.
• Familiarity with data management and visualization tools and collaborating with computational biology to analyze complex data sets emerging from clinical trials.
• Excellent written and oral communication skills, ability to present the results in clear and concise manner.
• Strong interpersonal, influencing and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts.

Additional Information

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html