Postdoctoral Scientist: UPS & Gene Regulation

Cedars-Sinai; Los Angeles (CA); On-site; USD 60,000 - 75,000; Full time

Job summary

Cedars-Sinai in Los Angeles seeks a Postdoctoral Scientist to join Predrag Jevtic, PhD, and elucidate how the ubiquitin-proteasome system regulates gene expression and cell fate. The role blends human stem cell and cancer models with diverse genomic and biochemical approaches, in a premier medical research environment.

The candidate will work independently with mentorship, contribute to grants, and co-author publications, advancing therapeutic strategies against disease.

Qualifications

• Doctorate in Biochemistry, Cell biology, Cancer biology, or related field.
• Experience designing experiments, analyzing data, and communicating findings.
• Strong publication record preferred.
• Knowledge of safety standards and maintenance of specialized equipment.

Responsibilities

• Designs and performs experiments and keeps detailed records.
• Analyzes and interprets data with the PI.
• May assist in preparation of grant proposals and publications.
• Contributes to presentations and manuscripts as author or co-author.

Skills

Independent researcher

Data analysis

Scientific communication

Biochemistry

Cell biology

Cancer biology

Laboratory safety

Education

Doctorate degree (MD, PhD) in Biochemistry, Cell biology, Cancer biology, or related field

Tools

Specialized equipment operation

Job description

Job Description

Principal Investigator, Predrag Jevtic, PhD is looking for a Postdoctoral Scientist to join the team!

The goal of the Jevtic laboratory is to elucidate the mechanisms by which the ubiquitin-proteasome system (UPS) regulates gene expression and influences cell fate decisions, and to determine how perturbations in these pathways contribute to human disease. Central to this pathway is the E3 ubiquitin ligase SCF-FBXL14, which interacts with the Groucho/TLE family of transcriptional co-repressors. TLEs are essential regulators of development that are frequently altered in cancer. Through its association with TLE proteins, SCF-FBXL14 controls diverse families of dozens lineage-specific repressive transcription factors that govern the development of most tissues and organ systems and their altered function causes congenital disorders and cancer. We will investigate how repressive protein complexes are managed on by the UPS to enable dynamic changes in gene expression and proper cellular identity.

In our lab we combine human stem cell and cancer models with genomic, proteomic, biochemical, and structural approaches. By bringing this mechanistic work together with the outstanding medical expertise, clinical resources, and research environment at Cedars-Sinai, we aim to uncover how defective ubiquitin-dependent control of gene expression causes disease and to translate these insights into new therapeutic strategies.

Are you ready to be a part of breakthrough research?

Working independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientists, the Postdoctoral Scientist will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. May assist in preparation of grant proposals. Participates in publications and presentations as author or co-author. Not responsible for generating grant funds.

Principal Responsibilities:

May assist in the preparation of grant proposals, but is not responsible for generating grant funds.

May participate in publications and presentations as author or co-author.

Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.

May develop, adapt, and implement new research techniques and protocols.

Analyzes interpret, summarizes, and compiles data.

Performs routine and complex laboratory procedure

Operates and maintains equipment and instruments.

May observe MD-patient or MD-human research subject interactions as it pertains directly to research being performed.

Experience in biochemistry, cell biology, cancer biology, or related fields is preferred.

Qualifications

Education:

Doctorate Degree (MD, PhD,) in Biochemistry, Cell biology, Cancer biology, or related field, required.

Work Experience:

• Demonstrated ability to design experiments, analyze data, and communicate scientific findings effectively.Highly motivated and works independently on research projects designed by a mentor (typically the PI) within the area of specialization.
• Highly motivated with a proven track of record of publications.
• Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, and operation and maintenance of specialized equipment.
• Knowledge of safety standards and maintenance of specialized equipment.

Experience in Cell biology, Protein purification and Biochemistry highly preferred.