Postdoctoral Scientist — Mitochondrial Bioenergetics

Eli Lilly and Company; Indianapolis (IN); On-site; USD 58,000 - 123,200; Full time

Job summary

Eli Lilly and Company in Indianapolis is seeking a post‑doctoral scientist to advance mitochondrial uncoupler research. You will establish and apply assays, screen novel small molecules, and explore mechanisms of action in collaboration with experts in bioenergetics and metabolic disease biology.

The role emphasizes rigorous experimental work, data interpretation, and communication, with opportunities to publish and present at conferences. This position is based in the United States.

Qualifications

• Ph.D. in a molecular biology/biochemistry related field.
• Authorized to work in the United States on a full‑time basis.

Responsibilities

• Develop and validate assays to identify small molecule uncouplers.
• Characterise in‑vitro mitochondrial uncoupling activity across cell types, tissues, and disease‑relevant systems.
• Work with and be mentored by experts in bioenergetics, molecular pharmacology, and metabolic disease biology.
• Design and execute small molecule screens to identify novel mitochondrial uncouplers, and characterise their mechanism of action, potency, selectivity, and safety margin using cutting‑edge industry technology and resources.
• Identify areas of key need across clinical development and champion creative solutions to address those needs.
• Present findings at conferences and publish in high‑quality peer‑reviewed journals.

Skills

Molecular biology

CRISPR gene editing

High-throughput screening

RT-qPCR

Protein analysis

Scientific communication

Education

Ph.D. in Molecular Biology/Biochemistry/Cell Biology/Pharmacology

Tools

TR-FRET

BRET

AlphaLISA

CETSA

NanoBRET

Mass spectrometry

Job description

Eli Lilly and Company in Indianapolis is seeking a post‑doctoral scientist to advance mitochondrial uncoupler research. You will establish and apply assays, screen novel small molecules, and explore mechanisms of action in collaboration with experts in bioenergetics and metabolic disease biology.

The role emphasizes rigorous experimental work, data interpretation, and communication, with opportunities to publish and present at conferences. This position is based in the United States.