Postdoctoral Scientist, AI Protein Design & Biotherapeutics

Merck; Cambridge (MA); On-site; USD 82,000 - 92,000; Full time

Job summary

Merck's Discovery Biologics in Cambridge, MA seeks a postdoctoral scientist to push boundaries in computational protein engineering and next-generation biotherapeutics design using state-of-the-art AI/ML and physics-based modeling. You will explore ensemble-aware design to impact therapeutic pipelines and develop tools for rapid data generation and validation.

The role emphasizes high-impact science, external publication opportunities, and collaboration within a Disruptive Technology group.

Qualifications

• PhD in Computational Biology, Bioinformatics, CS, Biophysics, Computational Chemistry, ML or related quantitative field.
• PhD or expected by Spring 2027.
• Experience applying computational protein design tools and structure prediction.

Responsibilities

• Implement benchmarking strategies for design approaches.
• Develop ensemble-aware generative design and scoring methods.
• Publish findings and share models and tools internally.

Skills

Python

ML frameworks

JAX

Team collaboration

Scientific communication

Education

PhD in Computational Biology or related

Tools

RFdiffusion

BoltzGen

ProteinMPNN

AlphaFold/Boltz/ESMFold

Job description

Merck's Discovery Biologics in Cambridge, MA seeks a postdoctoral scientist to push boundaries in computational protein engineering and next-generation biotherapeutics design using state-of-the-art AI/ML and physics-based modeling. You will explore ensemble-aware design to impact therapeutic pipelines and develop tools for rapid data generation and validation.

The role emphasizes high-impact science, external publication opportunities, and collaboration within a Disruptive Technology group.