Postdoctoral Scholar - Pediatrics

The Pennsylvania State University; Hershey (PA); On-site; USD 50,000 - 70,000; Full time

Job summary

A leading educational institution in Hershey, PA is seeking a Postdoctoral Scholar in the Department of Pediatric Hematology/Oncology. Candidates should have a PhD or MD/PhD in relevant fields. Responsibilities include researching molecular mechanisms in hematopoiesis and using various scientific approaches. Prior experience in gene regulation and peer-reviewed publications are preferred. This is a one-year limited-term appointment. Interested candidates must submit their CV and cover letter via email.

Qualifications

• Evidence of prior productive scientific work in the form of peer‑reviewed journal publications.
• Prior experience in the study of gene regulation, hematopoiesis, and/or use of mouse models (preferred).

Responsibilities

• Conduct research on the molecular mechanisms of 3D genome topology.
• Investigate the role of long noncoding RNAs in hematopoiesis.
• Utilize various approaches including biochemical and genomic methods.

Skills

Gene regulation

Hematopoiesis

Mouse models

Education

PhD or MD/PhD in molecular biology, biochemistry, bioinformatics, mouse genetics or a related field

Job description

APPLICATION INSTRUCTIONS

• CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, apply internally through Workday.
• CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.
• IF YOU ARE NOT a current employee or student, please click "Apply" and complete the application process for external applicants.

JOB DESCRIPTION AND POSITION REQUIREMENTS

The Department of Pediatric Hematology/Oncology at Penn State Hershey College of Medicine, in Hershey, PA, is currently accepting applications for a postdoctoral scholar. The lab focuses on delineating the epigenetic pathways that regulate normal hematopoiesis and to further determine how regulatory networks are perturbed in leukemia. Our current research focuses are:

• Investigating the underlying molecular mechanisms by which 3D genome topology controls the hematopoietic transcription program and lineage differentiation in normal and malignant hematopoiesis.
• Delineating the role of long noncoding RNAs in regulating CTCF boundary function during hematopoiesis and leukemogenesis.
• Epigenetic and transcriptional regulation of hematopoietic stem cell function.

We utilize a variety of approaches including biochemical, proteomic, genomic, genome editing, and mouse modeling to study these questions.

Representative recent publications from the lab include: Luo et al., Blood 2018, 132 (8): 837‑848; Luo et al., Cancer Cell 2019, 36: 645‑659; Zeisig et al., Science Translational Medicine 2021, 13 (482): eabc4822; Zhu et al., Nature Communications 2021, 12 (1): 1956. doi: 10.1038/s41467-021-22095-2; Li et al., 2020, NAR 48 (6): 3119‑3133.

Candidates should have obtained a PhD or an MD/PhD degree in the fields of molecular biology, biochemistry, bioinformatics, mouse genetics or a related field. The candidate should have evidence of prior productive scientific work in the form of publications in peer‑reviewed journals.

This is a limited‑term appointment funded for one year from date of hire.

RESPONSIBILITIES

As a postdoctoral scholar, you will conduct research focusing on the following areas:

• Investigating the underlying molecular mechanisms by which 3D genome topology controls the hematopoietic transcription program and lineage differentiation in normal and malignant hematopoiesis.
• Delineating the role of long noncoding RNAs in regulating CTCF boundary function during hematopoiesis and leukemogenesis.
• Epigenetic and transcriptional regulation of hematopoietic stem cell function.
• Utilizing biochemical, proteomic, genomic, genome editing, and mouse modeling approaches to address these questions.

QUALIFICATIONS

• PhD or MD/PhD in molecular biology, biochemistry, bioinformatics, mouse genetics or a related field.
• Evidence of prior productive scientific work in the form of peer‑reviewed journal publications.
• Prior experience in the study of gene regulation, hematopoiesis, and/or use of mouse models (preferred).
• Successful completion of a background check in accordance with University policies.

Interested candidates should upload their Curriculum Vitae and a cover letter describing their background and research interests in the application and additionally send to [e-mail].

CAMPUS SECURITY CRIME STATISTICS

Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR). The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters. The ASR is available for review here.

Employment with the University will require successful completion of background check(s) in accordance with University policies.

EEO IS THE LAW

Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.

Hershey, PA