Postdoctoral Scholar in Structural Mass Spectrometry

CWRU Center for Synchrotron Biosciences; Upton (NY); On-site; USD 65,000 - 80,000; Full time

Job summary

Le CWRU Center for Synchrotron Biosciences cherche un chercheur postdoctoral enthousiaste pour rejoindre son équipe en biologie structurale. Ce poste à temps plein, basé au National Synchrotron Light Source II, implique la contribution à des projets de recherche liés aux méthodes de spectrométrie de masse et à la collaboration avec des utilisateurs du faisceau XFP.

Qualifications

• Doit avoir un Ph.D. en domaine connexe.
• Compétences analytiques, orales et écrites fortes.
• Capacité à travailler de manière indépendante et en équipe.

Responsibilities

• Contribuer à la science du rayonnement synchrotron X.
• Assister des chercheurs visiteurs et étudiants dans les expériences.
• Soutenir l'opération quotidienne et le développement technologique.

Skills

Biologie structurale

Analyse des données de spectrométrie de masse

Travail en équipe

Education

Ph.D. en Chimie, Biochimie, Biophysique ou discipline connexe

Tools

Python

Job description

The Case Western Reserve University Center for Proteomics and Bioinformatics (CPB, https://case.edu/medicine/nutrition/case-center-proteomics-and-bioinformatics) seeks applications for a talented, enthusiastic postdoctoral scholar to join our Center for Synchrotron Biosciences (CSB, https://case.edu/medicine/csb/) team based full-time at the National Synchrotron Light Source II (NSLS-II, https://www.bnl.gov/nsls2) at Brookhaven National Laboratory on Long Island, NY. The CSB operates the 17-BM XFP Partner beamline at NSLS-II for access to the synchrotron X-ray footprinting structural mass spectrometry method, and promotes the application of this approach and other synchrotron-based tools to a variety of structural biology problems relevant to biomedical research.

The successful applicant will contribute to our synchrotron X-ray footprinting science and user support program. There will be opportunities to participate in ongoing research efforts in several areas, including development and characterization of novel X-ray footprinting labeling chemistries, development of methods for X-ray footprinting of the cellular proteome, and others. Opportunities exist to collaborate with current XFP beamline users and contribute to their use of X-ray footprinting towards their research projects, and to develop new collaborations applying X-ray footprinting. The successful applicant will also work with the beamline lead scientist to help support day-to-day operation and ongoing technological developments at the NSLS-II XFP beamline.

II. TECHNICAL SKILLS

Required technical skills include:

• Excellent background in structural biology, chemistry, or other related fields as evidenced by publication record and educational background.
• Experience with mass spectrometry data analysis in the life sciences.
• Ability to work independently and effectively in a collaborative team environment for solving scientific problems.

Preferred technical skills include:

• Familiarity with / experience in bacterial cell culture and protein expression methods.
• Familiarity with / experience in synchrotron-based structural biology methods.
• Experience / interest in Python programming for scientific applications and/or data analysis pipeline development.

III. SUPERVISORY RESPONSIBILITIES

Assist visiting scholars and students in the execution of X-ray footprinting experiments at the NSLS-II XFP beamline, including compliance with NSLS-II facility safety requirements.

IV. EDUCATION REQUIREMENTS

Minimum qualifications include a Ph.D. in Chemistry, Biochemistry, Biophysics, or a related discipline. The successful candidate must have strong analytical, oral, and written communication skills.

V. WORKING CONDITIONS

This position is based full-time off-campus at the National Synchrotron Light Source II, a US Department of Energy user facility at Brookhaven National Laboratory on Long Island, NY. The full salary range for this position is $65000 - $80000 / year. Salary offers will be commensurate with the final candidate’s qualification, education and experience.

VI. HOW TO APPLY

To apply, send a CV, cover letter describing your qualifications and interest in the position, and the names and contact details of three references to Erik Farquhar, [e-mail], XFP lead beamline scientist.