POSTDOCTORAL RESEARCHER - Ophthalmology - Harbour Lab

UT Southwestern Medical Center; Dallas (TX); On-site; USD 65,000 - 75,000; Full time

Benefits offered by this job

PPO medical plan

Paid Time Off

TRS retirement program

Parental leave

Wellness programs

Tuition reimbursement

PSLF eligible employer

Employee benefits

Job summary

UT Southwestern Medical Center in Dallas invites applications for a postdoctoral research position in the Department of Ophthalmology. The fellow will investigate genomic evolution, immune evasion, and metastasis in uveal melanoma using RNA-seq, ChIP-seq, ATAC-seq, scRNA-seq, and spatial transcriptomics, alongside cell culture and mouse models.

Ph.D. with relevant coursework is required; less than six years of postdoctoral experience is expected.

Qualifications

• Ph.D. with major coursework in the field of assignment.
• No postdoctoral experience required beyond Ph.D. (less than 6 years).
• Experience with genomic approaches and cancer biology is a plus.

Responsibilities

• Study genomic evolution, immune evasion, and metastasis in uveal melanoma.
• Utilize sequencing and epigenetic profiling to interrogate tumor biology.
• Contribute to manuscript preparation and data interpretation under supervision.

Skills

Genomics

Molecular biology

Cell culture

Education

Ph.D. in a relevant field

Tools

RNA-seq

ChIP-seq

ATAC-seq

scRNA-seq

Spatial transcriptomics

Job description

A postdoctoral research position is available in the Department of Ophthalmology at UT Southwestern Medical Center.

The postdoctoral fellow will study genomic evolution, immune evasion, and metastasis in uveal melanoma, a highly metastatic cancer of the eye. Our laboratory has discovered multiple genomic aberrations associated with metastasis in uveal melanoma, including bi-allelic mutational inactivation of the tumor suppressor BAP1, hemizygous change-of-function mutations in the splicing factor SF3B1, and aberrant expression of the cancer-testis antigen PRAME. We use a variety of techniques in cell biology, biochemistry, genetics, genomics, and epigenetics to elucidate how these aberrations interact with the tumor microenvironment to promote immune evasion and metastasis. The training experience will include the use of next generation sequencing methods such as RNA-seq, ChIP-seq, ATAC-seq, scRNA-seq, and spatial transcriptomics, as well as cell culture and genetically engineered mouse models.

Ph.D. with major coursework in the field of assignment, no experience required, and less than six (6) years of postdoctoral research experience

Applicants must submit a CV, a cover letter, and a list of three references.

UTSouthwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. Asan equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis ofrace, color, religion, national origin, sex,sexual orientation, gender identity, gender expression,age, disability, genetic information, citizenship status, or veteran status.

This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.

Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule.

To learn more about the benefits UT Southwestern offers, visit https://www.utsouthwestern.edu/employees/hr-resources/

Benefits

UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:

• PPO medical plan, available day one at no cost for full-time employee-only coverage
• 100% coverage for preventive healthcare – no copay
• Paid Time Off, available day one
• Retirement Programs through the Teacher Retirement System of Texas (TRS)
• Paid Parental Leave Benefit
• Wellness programs
• Tuition Reimbursement
• Public Service Loan Forgiveness (PSLF) Qualified Employer
• Learn more about these and other UTSW employee benefits!