Postdoctoral Research Fellow Venkatesh Lab

Mass General Brigham Incorporated; Boston (MA); Hybrid; USD 74,000 - 81,000; Full time

Job summary

The Venkatesh Lab at Brigham and Women's Hospital in Boston seeks a Postdoctoral Research Fellow to investigate neuron-cancer communication using electrophysiology, optogenetics, and advanced imaging. You will develop experiments to map neural circuits that influence tumor growth and progression, and collaborate across neuroscience and cancer biology teams.

Applicants should have a PhD in neuroscience or related field with strong publishing records and experience in patch-clamp, in vivo

Qualifications

• PhD in neuroscience, cancer biology or related field with strong publication record.
• Experience with electrophysiology and neural modulation techniques.
• Proficiency in molecular biology and data analysis; independent work ethic.

Responsibilities

• Lead independent and collaborative projects on neuron-cancer interactions.
• Design experiments to study electrical components of cancer pathophysiology.
• Mentor trainees and present findings at meetings and conferences.

Skills

Electrophysiology

Optogenetics

In vivo recordings

Two-photon imaging

CRISPR

Data analysis

Education

PhD in Neuroscience

Cancer biology or related field

Tools

Patch-clamp

Calcium imaging

qPCR/Western blot

FACS

Spatial transcriptomics

Job description

## Postdoctoral Research Fellow Venkatesh LabApply: Onsite: Boston-MA: Posted 9 Days Ago: RQ4081101Site: The Brigham and Women's Hospital, Inc.Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.**Job Summary**The Venkatesh Lab at Brigham and Women’s Hospital (BWH) and Harvard Medical School is a pioneering research group at the forefront of cancer neuroscience, exploring the intersection of cancer biology and neuroscience. Our work focuses on uncovering the electrical and molecular mechanisms driving neuron-cancer communication. By leveraging state-of-the-art technologies to map neural circuitry and modulate neural activity, we aim to bridge the gap between cancer biology and systems neuroscience, offering new therapeutic possibilities. Our research characterizes and therapeutically targets neural pathways in both the PNS and CNS, with the goal of developing innovative treatments by exploiting tumor microenvironment dependencies at the neuron-tumor interface. This interdisciplinary approach combines cutting-edge neuroscience techniques with cancer biology to redefine our understanding of malignancy and its systemic connectivity with the brain and body. Position Overview We are seeking a highly motivated and creative Postdoctoral Research Fellow to join our team. The ideal candidate will have a strong background in neuroscience techniques and a passion for exploring the electrical underpinnings of cancer progression. This role offers a unique opportunity to contribute to groundbreaking research at the intersection of two constantly evolving fields, with direct implications for the development of novel cancer therapies.**Qualifications**Key ResponsibilitiesResearch & Experimental Design-Lead and execute independent and collaborative research projects focused on neuron-cancer interactions, particularly within the PNS-tumor interface.-Design and perform experiments to investigate the electrical components of cancer pathophysiology, including neural modulation of tumor growth and malignant transformation.-Utilize state-of-the-art neuroscience techniques (e.g., electrophysiology, optogenetics, chemogenetics, calcium imaging, in vivo neural recordings, and behavioral assays) to dissect neural circuitry involved in cancer progression. -Develop and apply molecular and cellular biology techniques (e.g., CRISPR, single-cell RNA sequencing, spatial transcriptomics, and immunofluorescence) to characterize neural and tumor cell interactions.-Map systemic brain-body connectivity and its role in cancer biology using advanced imaging (e.g., two-photon microscopy, light-sheet microscopy) and tracing methods. Technical Expertise- Experience with rodent models (e.g., mouse handling, surgical procedures, stereotaxic injections) is required.- Experience with neural modulation techniques such as Optogenetics, chemogenetics (DREADDs), or pharmacological manipulation of neural circuits.- Skilled in advanced imaging including Confocal microscopy, two-photon imaging, light-sheet microscopy, or super-resolution imaging. - PCR, qPCR, Western blotting, immunofluorescence, FACS, CRISPR-Cas9, viral vector design, and in vitro cell culture (primary neurons, iPSCs, or cancer cell lines).- Proficiency in data analysis and visualization using tools such as MATLAB, Python, R, or FIJI/ImageJ. Experience with neural data analysis (e.g., Spike2, NeuroExplorer, or custom scripts) is a plus.- Familiarity with electrophysiology, ideally Patch-clamp recording is a plus. Collaboration & Communication -Collaborate with a multidisciplinary team of neuroscientists and cancer biologists at all stages of training.-Present research findings at lab meetings, departmental seminars, and national/international conferences.-Prepare manuscripts for publication in high-impact journals and contribute to grant proposals.-Mentor graduate students, undergraduate researchers, and technical staff as needed. Collaboration & Communication-Collaborate with a multidisciplinary team of neuroscientists and cancer biologists at all stages of training.-Present research findings at lab meetings, departmental seminars, and national/international conferences.-Prepare manuscripts for publication in high-impact journals and contribute to grant proposals.-Mentor graduate students, undergraduate researchers, and technical staff as needed.-Maintain accurate and detailed laboratory records and ensure compliance with institutional, ethical, and regulatory standards (e.g., IACUC, biosafety). Qualifications & RequirementsPh.D. in Neuroscience, Cancer Biology, Molecular/Cellular Biology, Bioengineering, or a related field.Strong publication record demonstrating expertise in neuroscience techniques and/or cancer biology.Ability to work independently and as part of a collaborative, fast-paced research team.Excellent written and verbal communication skills in English. Hands-on experience with at least 3 of the following techniques:-Electrophysiology (patch-clamp, in vivo recordings) -Optogenetics/chemogenetics-Advanced microscopy (two-photon, confocal, light-sheet) -In vivo murine models (rodent survival surgery, ) Preferred Qualifications-Experience in cancer neuroscience, neuro-oncology, or tumor microenvironment research.-Familiarity with single-cell omics (scRNA-seq, spatial transcriptomics) or bioinformatics analysis.-Experience with in vivo imaging of neural activity (e.g., GCaMP, voltage indicators).-Knowledge of neuroimmunology, neuroinflammation, or glia-neuron interactions in the context of disease. -Prior work with patient-derived samples or co-culture systems. **Additional Job Details (if applicable)**## **The salary for this position ranges from $73,544 to $81,199.** **Additional Job Details (if applicable)****IMPORTANT – APPLICATION INSTRUCTIONS****Please do not apply through the Workday “Apply” button.****This position is being posted for informational purposes only. To be considered, please submit the following directly to** **Hamsa Venkatesh [e-mail]. by clicking the link below:****CV/resume****Cover letter****Contact information for three references** [[e-mail]] Please note: Applications submitted through Workday will not be forwarded to the hiring manager and may not be reviewed. **Remote Type**Onsite**Work Location**60 Fenwood Road**EEO Statement:**2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.