Postdoctoral Research Fellow - Jones Lab

Dana-Farber Cancer Institute; Boston (MA); On-site; USD 72,000 - 76,000; Full time

Job summary

The Jones Lab at Dana-Farber Cancer Institute in Boston seeks a highly motivated Postdoctoral Research Fellow to develop chemical probes for therapeutic modalities. The role spans biochemical, biophysical, and cellular assays with in vivo validation, leveraging state-of-the-art facilities in chemistry, biophysics, and mass spectrometry.

Responsibilities include screening compounds, data interpretation, and exploring molecular modes of action, with contribution to publications and grants.

Qualifications

• PhD in chemical biology or related discipline required.
• Expert in protein preparation, biochemical assay development and compound screening.
• Experience in cell-based assay development and immunoblot.
• Evidence of consistent scientific innovation and publications in peer-reviewed journals.

Responsibilities

• Develop and apply biochemical, biophysical, and cellular assays for chemical probes with cellular and in vivo validation.
• Screen compounds and analyze data to inform probe quality and insights.
• Elucidate molecular modes of action of chemical probes.
• Maintain accurate lab records and contribute to publications and grants.

Skills

Protein preparation

Biochemical assay development

Compound screening

Cell-based assay development

Immunoblot

Excellent communication

Publications track record

Independent and collaborative work

Organizational skills

Data analysis

Education

PhD in chemical biology or related discipline

Job description

The Jones Lab is developing next-generation covalent chemical biology with the objective of expanding the druggable proteome. We seek a highly motivated individual to join our collaborative research efforts as a POSTDOCTORAL RESEARCH FELLOW who will work on chemical biology projects directed towards the development of novel therapeutic modalities.

We are based at Dana-Farber Cancer Institute in Longwood Center, and we have access to state-of-the-art facilities for chemistry, biophysics, biochemistry, structural biology, and mass spectrometry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

• Develop and apply biochemical, biophysical, and cellular assays to enable the development of chemical probes suitable for cellular and in vivo pharmacological validation
• Screen compounds; analyze and interpret data
• Explore and elucidate molecular modes-of-action of chemical probes
• Maintain accurate lab records and documentation
• Contribute to publications and grant proposals.
• Stay current with scientific advances in the fields of chemical biology and screening technologies, and apply emerging techniques and insights to their own research

Qualifications And Experience

• PhD degree in chemical biology or a related discipline
• Expert in protein preparation, biochemical assay development and compound screening
• Expert in chemical biology techniques used to assess interactions between proteins and small molecules
• Experience in cell-based assay development, compound screening and immunoblot
• Experience in chemoproteomics is desirable
• Excellent communication and presentation skills
• Evidence of consistent scientific innovation. Proven track record of publications in peer reviewed journals
• Able to work independently as well as in a collaborative team environment
• Excellent organizational and prioritization skills. Strong attention to detail
• Able to collect and analyze experimental data, prepare research publications, and communicate results

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$72,000.00 - $76,385.00