Postdoctoral Research Fellow - Center for Discovery and Innovation

John Theurer Cancer Center at Hackensack University Medical Center; Nutley (NJ); Sur place; USD 56 000 - 68 000; Plein temps

Résumé du poste

Hackensack Meridian Health's Center for Discovery and Innovation is actively seeking a Postdoctoral Research Fellow to join a multidisciplinary, well-funded program focused on discovering and developing novel therapeutics for infectious diseases of global health importance.

The fellow will apply advanced analytical, pharmacological, and MS-based approaches to characterize drug candidates from discovery through preclinical development.

Qualifications

• A Ph.D. degree in scientific or related discipline.
• Minimum publication or in preparation of one article as first author in a reputable peer-reviewed journal.
• Excellent written and verbal skills
• Good problem solving skills.
• Ability to conduct independent research.
• Ability to work effectively in a team.
• Lab specific techniques. (Varies by lab)
• Proficient computer skills including but not limited to Microsoft Office and Google Suite platforms.

Responsabilités

• Develop and apply advanced HPLC-MS/MS and high-resolution mass spectrometry methods for metabolite identification and drug characterization.
• Conduct quantitative bioanalysis, PK/PD modeling and preclinical pharmacology studies.
• Develop and apply laser capture microdissection with LC-MS/MS (LCM-LC-MS/MS) to investigate spatial drug distribution and tissue penetration.
• Collaborate with microbiology, medicinal chemistry, pharmacology and drug development teams to integrate data for translational progression.

Connaissances

Excellent communication

Independent research

Teamwork

Problem solving

Formation

PhD in science or related field

Description du poste

Overview

The Center for Discovery and Innovation- CDI was established by Hackensack Meridian Health (HMH) as an academic basic and translational research enterprise to rapidly translate science innovation to the clinic and to improve outcomes for patients with cancer, infectious diseases, autoimmune disease and other acute and chronic diseases. The CDI has grown rapidly since its origins in 2019, and now has 39 labs, 200+ scientists and allied personnel supported by 78 NIH and DoD grants and more than 87 other grants and contracts. Areas of expertise include genomics, epigenetics, drug resistance, stem cell biology, drug discovery, diagnostics and biomarker development, rheumatology and pharmacology.

The Center for Discovery and Innovation- CDI was established by Hackensack Meridian Health (HMH) as an academic basic and translational research enterprise to rapidly translate science innovation to the clinic and to improve outcomes for patients with cancer, infectious diseases, autoimmune disease and other acute and chronic diseases. The CDI has grown rapidly since its origins in 2019, and now has 39 labs, 200+ scientists and allied personnel supported by 78 NIH and DoD grants and more than 87 other grants and contracts. Areas of expertise include genomics, epigenetics, drug resistance, stem cell biology, drug discovery, diagnostics and biomarker development, rheumatology and pharmacology.

The Center for Discovery and Innovation (CDI) is recruiting a highly motivated Postdoctoral Research Fellow to join a multidisciplinary and well-funded research program focused on the discovery and development of novel therapeutics for infectious diseases of global health importance. Our research programs span a broad range of pathogens and diseases, including tuberculosis and other mycobacterial infections, viruses of pandemic concern, invasive fungal infections, including Candida, Aspergillus, and other priority fungal pathogens, and ESKAPE bacterial pathogens. The program is supported by a diverse portfolio of competitive funding from the National Institutes of Health, including R01 and U19 awards, BARDA, and the Bill & Melinda Gates Foundation, providing strong resources and opportunities for innovative translational research. The fellow will apply advanced analytical, pharmacological, and mass spectrometry-based approaches to characterize drug candidates and support their progression from early discovery through advanced preclinical development.

Responsibilities will include developing and applying advanced HPLC-MS/MS and high-resolution mass spectrometry methods for metabolite identification and drug characterization, quantitative bioanalysis, pharmacokinetic analysis, drug metabolism studies, and drug formulation development. The fellow will also contribute to PK/PD modeling and the design and analysis of preclinical pharmacology studies. A major component of the position will involve developing and applying laser capture microdissection coupled with quantitative LC-MS/MS (LCM-LC-MS/MS) to investigate spatial drug distribution and drug penetration into tissues and infectious lesions. The fellow will work closely with scientists across microbiology, medicinal chemistry, pharmacology, and drug development to integrate bioanalytical, PK, PD, and spatial pharmacology data and help advance promising anti-infective drug candidates toward clinical development.

This position offers an exceptional opportunity to gain broad, hands-on expertise in mass spectrometry, bioanalysis, pharmacokinetics, PK/PD, drug metabolism, formulation, and translational drug development within a highly collaborative and well-supported infectious disease research environment.

A day in the life of a Postdoc at Hackensack Meridian Health includes:

• Conducts research under direct supervision.
• Collects, analyzes and interprets data.
• Creates reports from analysis of initial observations and conclusions.
• Presents findings to higher level staff.
• Presents results in internal and external research forums such as scientific conferences, lab meetings and institutional seminars.
• Handles moderately complex issues and problems and refers more complex issues to higher-level staff.
• Participates in grant and manuscript writing, as appropriate.
• Other duties and/or projects as assigned.
• Adheres to HMH Organizational competencies and standards of behavior.

Qualifications

Education, Knowledge, Skills and Abilities Required

• A Ph.D. degree in scientific or related discipline.
• Minimum publication or in preparation of one article as first author in a reputable peer-reviewed journal.
• Excellent written and verbal skills
• Good problem solving skills.
• Ability to conduct independent research.
• Ability to work effectively in a team.
• Lab specific techniques. (Varies by lab)
• Proficient computer skills including but not limited to Microsoft Office and Google Suite platforms.

Education, Knowledge, Skills And Abilities Preferred

• Lab Specific.

Compensation

Minimum rate of $62,233.60 Annually

HMH is committed to pay equity and transparency for our team members. The posted rate of pay in this job posting is a reasonable good faith estimate of the minimum base pay for this role at the time of posting in accordance with the New Jersey Pay Transparency Act and does not reflect the full value of our market-competitive total rewards package.

Job Duties

The starting rate of pay is provided for informational purposes only and is not a guarantee of a specific offer. Posted hourly rates may be stated as an annual salary in the offer and posted annual salaries may be stated as an hourly rate in the offer, depending on the level and nature of the job duties and credentials of the candidate. The base compensation determined at the time of the offer may be different than the posted rate of pay based on a number of non-discriminatory factors, including but not limited to:

• Labor Market Data: Compensation is benchmarked against market data to ensure competitiveness.
• Experience: Years of relevant work experience.
• Education and Certifications: Level of education attained, including specialized certifications, credentials, completed apprenticeship programs or advanced training.
• Skills: Demonstrated proficiency in relevant skills and competencies.
• Geographic Location: Cost of living and market rates for the specific location.
• Internal Equity: Compensation is determined in a manner consistent with compensation ranges for similar roles within the organization.
• Budget and Grant Funding: Departmental budgets and any grant funding associated with the job position may impact the pay that can be offered.

Some jobs may also be eligible for performance-based incentives, bonuses, or commissions not reflected in the starting rate. Certain positions may also be eligible for shift differentials for work performed on evening, night, or weekend shifts.

In addition to our compensation for full-time and part-time (20+ hours/week) job positions, HMH offers a comprehensive benefits package, including health, dental, vision, paid leave, tuition reimbursement, and retirement benefits.

HACKENSACK MERIDIAN HEALTH (HMH) IS AN EQUAL OPPORTUNITY EMPLOYER

All qualified applicants will receive consideration for employment without regard to age, race, color, creed, religion, sex, sexual orientation, gender identity or expression, pregnancy, breastfeeding, genetic information, refusal to submit to a genetic test or make available to an employer the results of a genetic test, atypical heritage cellular or blood trait, national origin, nationality, ancestry, disability, marital status, liability for military service, or status as a protected veteran.

Our Network

Hackensack Meridian Health (HMH) is a Mandatory Influenza Vaccination Facility

As a courtesy to assist you in your job search, we would like to send your resume to other areas of our Hackensack Meridian Health network who may have current openings that fit your skills and experience.