Postdoctoral Research Fellow

1300 Massachusetts General Physicians Organization, Inc.; Boston (MA); Hybrid; USD 60,000 - 80,000; Full time

Job summary

The Morini Laboratory at Massachusetts General Hospital is seeking a Postdoctoral Research Fellow to join our translational research team. You will focus on developing therapeutic strategies for Familial Dysautonomia, conducting in vivo studies, and applying molecular approaches to assess outcomes.

This hybrid role requires a Ph.D. in relevant fields and offers the opportunity to collaborate with top researchers in a state-of-the-art environment.

Qualifications

• Ph.D. preferred.
• Excellent English verbal and written communication skills.
• Ability to work independently and in a team.

Responsibilities

• Design and conduct in vivo efficacy studies.
• Perform downstream analyses like RNA/protein quantification.
• Lead development of therapeutic delivery and molecular assays.
• Collaborate with researchers and mentor junior lab members.
• Prepare manuscripts and present findings.

Skills

Molecular biology techniques

Genetic methodologies

Cell culture experience

Rodent models experience

Microscopy imaging and immuno-cytochemistry

Education

Doctoral degree in neuroscience, cell or molecular biology, human genetics, biochemistry, or related field

Job description

Job Summary

The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease. This project aims to evaluate the efficacy of gene editing approaches and small‑molecule splicing modulators in a mouse model of FD. The successful candidate will lead in‑vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state‑of‑the‑art resources and a vibrant scientific community.

Duties and Responsibilities

• Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
• Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.
• Lead the development and optimization of therapeutic delivery and molecular assays.
• Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications.

Qualifications

Doctoral degree in neuroscience, cell or molecular biology, human genetics, biochemistry, or a related field (Ph.D. preferred). Excellent English verbal and written communication skills. Ability to work independently and in a team.

Desired Skills and Competencies

• Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting).
• Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing.
• Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization.
• Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.
• Some experience with microscopy imaging and immuno‑cytochemistry (IHC) techniques.
• Histological and immune‑histochemical techniques.
• First (or co‑first) author of one or more peer‑reviewed scientific publications.
• Excellent English verbal and written communication skills.
• Ability to work both independently and in a team.

Location

Hybrid – 185 Cambridge Street, Cambridge, MA.

EEO Statement

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.