Postdoctoral Positions in Functional Transcriptomics, Cell Signaling, and Cancer Immunotherapy

University of Pennsylvania; Philadelphia (Philadelphia County); On-site; USD 60,000 - 75,000; Full time

Job summary

The Thomas-Tikhonenko laboratory at the University of Pennsylvania: Perelman School of Medicine is recruiting postdoctoral fellows to pursue funded basic and translational research projects focused on aberrant mRNA splicing in cancer vulnerabilities and new therapy targets. The work spans hematologic malignancies and solid tumors and combines mechanistic studies with immunotherapy development.

Candidates should have a PhD, MD, DVM, or equivalent and expertise in RNA biology, cancer genomics,

Qualifications

• PhD/MD/DVM or equivalent doctoral degree.
• Demonstrated expertise in RNA biology, cancer genetics/genomics, cell signaling, immunotherapy, or bioinformatics.
• Eligibility for federal training grants is a plus but not required.

Responsibilities

• Pursue newly funded basic and translational research projects.
• Elucidate the role of aberrant mRNA splicing in cancer vulnerabilities and identify new therapy targets.
• Collaborate with a multidisciplinary team within UPenn/CHOP and related institutes.

Skills

RNA biology

Cancer genetics/genomics

Cell signaling

Immunotherapy

Bioinformatics

Education

PhD, MD, DVM, or equivalent doctoral degrees

Job description

University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral

Location

University of Pennsylvania - Perelman School of Medicine

Open Date

Oct 27, 2026

Description

The Thomas-Tikhonenko laboratory is recruiting postdoctoral fellows to pursue newly funded basic and translational research projects aimed at elucidating the role of aberrant mRNA splicing in defining cancer vulnerabilities and identifying new targets for therapy. Our research spans hematologic malignancies and solid tumors, combining mechanistic studies with the development of novel immunotherapies. Please visit the lab website for ongoing projects, recent publications, and current members. We are located in the Colket Translational Research Building of Children's Hospital of Philadelphia, which shares a contiguous campus with the University of Pennsylvania's Perelman School of Medicine. This setting provides ample opportunities for interactions with the NCI-designated Abramson Cancer Center, the Institute for Immunology and Immune Health, the Institute for Biomedical Informatics, and other research programs.

Qualifications

We seek ambitious scientists who thrive on challenges, enjoy working in a highly collaborative and dynamic research environment, and are eager to make their marks. Strong candidates will hold PhD, MD, DVM, or equivalent doctoral degrees and have demonstrated expertise in at least one of the following fields: RNA biology, cancer genetics/genomics, cell signaling, immunotherapy, or bioinformatics. Recent graduates with strong research accomplishments in adjacent areas are also encouraged to apply. Eligibility for federal training grants is a plus but not a requirement.

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.