Postdoctoral Position Mechanisms of Glycan Biosynthesis and Function

GlycoData; Bethesda (MD); On-site; USD 65,000 - 75,000; Full time

Job summary

The Samara Lab at the National Institute of Dental and Craniofacial Research (NIDCR) at the NIH invites applications for a postdoctoral researcher to join our group in Bethesda, MD. We integrate in vitro biochemical and structural approaches with in cellulo models and patient data to study glycosyltransferases and their glycans, aiming to understand how their dysregulation affects human health.

Ideal candidates have a Ph.D.

Qualifications

• Ph.D. in biomedical sciences is required.
• Less than 1 year of postdoctoral experience.
• Strong verbal and writing skills; experience in structural biology and biochemistry.

Responsibilities

• Lead an independent postdoctoral project aligned with the lab's mission.
• Apply in vitro biochemical and structural methods and work with in cellulo models and patient data.
• Collaborate with NIH colleagues and contribute to the lab's goals in glycosyltransferase research.

Skills

Structural biology

Biochemistry

Membrane protein purification

Verbal and written communication

Education

Ph.D. in biomedical sciences

Job description

National Institute of Dental and Craniofacial Research at NIH Bethesda, MD Posted October 16, 2026

Position Description

The Samara Lab at the National Institute of Dental and Craniofacial Research (NIDCR) at the NIH is seeking a postdoctoral researcher to join our group. We integrate in vitro biochemical and structural methods with in cellulo models and patient data to study the functions of glycosyltransferases and the glycans they produce, and understand how their dysregulation impacts human health. The NIH offers unique opportunities to collboarate with people from various fields, including clinicians, and use in vivo and patient data to stimulate research questions. The Samara Lab is looking to support a motivated, creative, independent junior researcher who can lead their own project within the mission of the lab. In your application, please submit a 1 page research statement describing your interests and aims as a future fellow in the lab, centering around glycosyltransferases and glycans. Please use your own voice, not AI, to generate the document.

Currently, one project in the lab is to understand how a family of enzymes called GalNAc-Ts, which initiate the first step in mucin-type O-glycosylation, recognize and modify their substrates. Our lab has made major advances in studying their substrate specificifies (Collette et al. Sci. Adv. 2024, Samara, Glycobiology 2025), their mechanism of glycosylation in protozoan pathogens (Kumar et al. Nat. Comm. 2024), and how they modulate development and drive disease (Fernandez et al. Nat. Comm. 2019, Kumar et al. Comm. Biol. 2026, Zhang et al. PNAS 2026). A second project in the lab centers on bacterial O-glycosyltransferases that synthesize polysaccharide based virulence factors such as capsular polysaccharide (CPS), lipopolysaccharide (LPS), and exopolysaccharides (EPS) in the oral biofilm. Understanding how bacterial glycosyltransferases synthesize glycan structures at atomic resolution will provide insight into targeting and inhibiting these enzymes in the treatment of bacterial infections in the oral cavity.

Qualifications

We are seeking a highly motivated candidate with a Ph.D. in the biomedical sciences and less than 1 year of postdoctoral experience. The candidate should have strong verbal and writing skills, and experience in structural biology and biochemistry. Knowledge and experience in the purification and structural biology of membrane proteins is a plus. Salary is commensurate with research experience and accomplishments.

Position overview

Organization National Institute of Dental and Craniofacial Research at NIH